Detailed information of TA system TA021709

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 792869..793508
• Replicon: chromosome
• Accession: NC_008391
• Organism: Burkholderia ambifaria AMMD

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: BAMB_RS19580
• Protein ID: WP_011658906.1
• Coordinates: 792869..793279 (-)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: Q0B8R6
• Locus tag: BAMB_RS19585
• Protein ID: WP_006753828.1
• Coordinates: 793272..793508 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAMB_RS19545	788224..789387	+	1164	WP_041491473.1	MFS transporter	-
BAMB_RS19550	789411..789659	-	249	WP_012366135.1	hypothetical protein	-
BAMB_RS19555	789935..790465	-	531	WP_011658903.1	transferase hexapeptide repeat family protein	-
BAMB_RS19560	790469..790729	-	261	Protein_677	electron transfer flavoprotein subunit alpha/FixB family protein	-
BAMB_RS34105	790731..790844	+	114	Protein_678	4-hydroxy-2-oxovalerate aldolase	-
BAMB_RS19565	791139..791402	-	264	WP_006751842.1	translation initiation factor IF-1	-
BAMB_RS19570	791862..792065	-	204	WP_006751843.1	cold-shock protein	-
BAMB_RS19575	792420..792656	-	237	Protein_681	biphenyl 2,3-dioxygenase	-
BAMB_RS19580	792869..793279	-	411	WP_011658906.1	type II toxin-antitoxin system VapC family toxin	Toxin
BAMB_RS19585	793272..793508	-	237	WP_006753828.1	DNA-binding protein	Antitoxin
BAMB_RS19590	793755..794957	-	1203	WP_041491474.1	DUF2029 domain-containing protein	-
BAMB_RS19595	795184..796410	+	1227	WP_041491475.1	acyltransferase	-
BAMB_RS19605	797135..798004	-	870	WP_011658910.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (1-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 15067.21 Da
• Isoelectric Point: 6.9900

>T21709 WP_011658906.1 NC_008391:c793279-792869 [Burkholderia ambifaria AMMD]
MIDTNVISEIRKGKRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHPQASALEAWMATILSGYASNILP
VDIETAQMWGHLRVPDPAHALDHLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Nucleotide

• Length: 411 bp

>T21709 NC_008391:c793279-792869 [Burkholderia ambifaria AMMD]
TTGATTGATACGAACGTCATCAGCGAGATCAGAAAGGGCAAGCGAACCAACCGCGGCGTGCGCGCGTTCTTCAGGCAGGC
GGAGGCCGACGCGAGCCCGCTTTACCTGTCGGTCGTGACGGTGGCCGAACTGCGGCGCGGCGTCGACCTGATCCGTCATC
GCGGCGATCATCCGCAGGCGTCGGCGCTCGAGGCATGGATGGCGACGATCCTGTCCGGCTATGCGTCGAACATCCTGCCC
GTCGATATCGAGACCGCCCAGATGTGGGGCCATTTGCGCGTGCCCGATCCGGCCCACGCCCTCGATCACCTGATCGCGGC
CACCGCGCTGATCAACGATCTGACGGTCGTTACCCGCAATGTCGACGATTTCGCTCGCACCGGCGTCCGGCTGCTGAACC
CGTTCGATTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8682.73 Da
• Isoelectric Point: 5.0774

>AT21709 WP_006753828.1 NC_008391:c793508-793272 [Burkholderia ambifaria AMMD]
MANLLVRNVDDSIVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLMSMPDVGEDADFQRVQDSGEVRRVFD

Nucleotide

• Length: 237 bp

>AT21709 NC_008391:c793508-793272 [Burkholderia ambifaria AMMD]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACAGTATCGTTCAGAGCCTGCGCGAGCAGGCCGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGGGCCATTCTGGCCGAGGCGCTCGGCCGGCCGAAACGACGGACATTCGCGCAAGTGCTGATGA
GCATGCCGGACGTCGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCCGGCGAGGTCAGGCGTGTTTTTGATTGA

Structures

Antitoxin

• AlphaFold DB: A0A2S9KQ31