Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4879892..4880523 Replicon chromosome
Accession NZ_CP083690
Organism Serratia sp. HRI

Toxin (Protein)


Gene name vapC Uniprot ID A0A5P6GW52
Locus tag GF111_RS23305 Protein ID WP_047730458.1
Coordinates 4880125..4880523 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3SVC2
Locus tag GF111_RS23300 Protein ID WP_047730457.1
Coordinates 4879892..4880125 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GF111_RS23275 (GF111_23275) 4875044..4876660 + 1617 WP_047730456.1 methyl-accepting chemotaxis protein -
GF111_RS23280 (GF111_23280) 4876698..4877570 + 873 WP_025159837.1 protein-glutamate O-methyltransferase CheR -
GF111_RS23285 (GF111_23285) 4877570..4878619 + 1050 WP_015378262.1 chemotaxis response regulator protein-glutamate methylesterase -
GF111_RS23290 (GF111_23290) 4878722..4879111 + 390 WP_004934862.1 chemotaxis response regulator CheY -
GF111_RS23295 (GF111_23295) 4879122..4879766 + 645 WP_004934858.1 protein phosphatase CheZ -
GF111_RS23300 (GF111_23300) 4879892..4880125 + 234 WP_047730457.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
GF111_RS23305 (GF111_23305) 4880125..4880523 + 399 WP_047730458.1 type II toxin-antitoxin system VapC family toxin Toxin
GF111_RS23310 (GF111_23310) 4880650..4881801 + 1152 WP_047730459.1 flagellar biosynthesis protein FlhB -
GF111_RS23315 (GF111_23315) 4881794..4883872 + 2079 WP_038876828.1 flagellar biosynthesis protein FlhA -
GF111_RS23320 (GF111_23320) 4883872..4884276 + 405 WP_047730460.1 flagellar protein FlhE -
GF111_RS23325 (GF111_23325) 4884605..4885420 + 816 WP_047730461.1 5'-nucleotidase, lipoprotein e(P4) family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-45)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14960.14 Da        Isoelectric Point: 7.4664

>T217088 WP_047730458.1 NZ_CP083690:4880125-4880523 [Serratia sp. HRI]
MFSHMLDTNIVIYVIKRRPLEVLEVFNRYAGKMVISSITYGELVHGVENSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAVLERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Download         Length: 399 bp

>T217088 NZ_CP113808:3037651-3037821 [Shewanella sp. DAU305]
TTGTTTAAAGCATTAGGTGCAGACGTTTCCGAAAGAGCAGGCTCTCGAGTCGCTGTTGTGCTGTTTGATGAAGTACGAGT
ATTTCATCGGCCCCACCCATCTCCGAATACGGATAAAAGAGCAATTACCAGTATTTGGAAATGGCTAGAAGAGAACGAGG
TGAAACCATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8841.85 Da        Isoelectric Point: 4.7815

>AT217088 WP_047730457.1 NZ_CP083690:4879892-4880125 [Serratia sp. HRI]
MALGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Download         Length: 234 bp

>AT217088 NZ_CP113808:3037818-3038150 [Shewanella sp. DAU305]
ATGAACATAATGGTGGTTGACGGTTATAAGGCCAAAATTGAATATGACCCTCAACTCGATCAGTTTCGAGGAGAGATTCT
TGGACTTAATGGAAGTGCAGATTTTTACGGCACAAATCCTGCCAGTCTTCGTCGGGAATTCAAAAACTCACTCAAAGTAT
TCCTTGAAGTATGTAAAGAAAAGGGAATCAAACCAAGCAAGGAGTTTTCTGGAAAATTTAATCTTCGCATACCGCCGCAT
TTACATGCTGAAGTAGCTGCACGAGCTTCTGCTGAGGGCAAAAGTATCAATCAATGGGTTTCTGAAGTGCTCAGAAATTC
TGTAAGTGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P6GW52

Antitoxin

Source ID Structure
AlphaFold DB A0A0G3SVC2

References