Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 4117087..4117649 Replicon chromosome
Accession NZ_CP083690
Organism Serratia sp. HRI

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag GF111_RS19700 Protein ID WP_224217748.1
Coordinates 4117293..4117649 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag GF111_RS19695 Protein ID WP_004936539.1
Coordinates 4117087..4117296 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GF111_RS19670 (GF111_19670) 4113235..4113561 + 327 WP_004936551.1 phage holin, lambda family -
GF111_RS19675 (GF111_19675) 4113551..4113952 + 402 WP_038881240.1 M15 family metallopeptidase -
GF111_RS19680 (GF111_19680) 4113949..4114329 + 381 WP_047730130.1 DUF2570 family protein -
GF111_RS19685 (GF111_19685) 4114310..4114483 + 174 WP_038881246.1 hypothetical protein -
GF111_RS19690 (GF111_19690) 4114699..4116978 + 2280 WP_038881248.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
GF111_RS19695 (GF111_19695) 4117087..4117296 + 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
GF111_RS19700 (GF111_19700) 4117293..4117649 + 357 WP_224217748.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
GF111_RS19705 (GF111_19705) 4117660..4118598 - 939 WP_047730132.1 homocysteine S-methyltransferase -
GF111_RS19710 (GF111_19710) 4118588..4119997 - 1410 WP_038881254.1 S-methylmethionine permease -
GF111_RS19715 (GF111_19715) 4120175..4121014 + 840 WP_147190559.1 ChaN family lipoprotein -
GF111_RS19720 (GF111_19720) 4121117..4121914 + 798 WP_055317351.1 TonB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(20-114)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13152.94 Da        Isoelectric Point: 4.7274

>T217087 WP_224217748.1 NZ_CP083690:4117293-4117649 [Serratia sp. HRI]
MIFLTAEDIAEFNAEIVPHGRQEGRKVEAAANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEQLRLLTE

Download         Length: 357 bp

>T217087 NZ_CP113808:1216465-1217766 [Shewanella sp. DAU305]
ATGAGTACTTCCAAAAAGCTCACGTTAGAGATGCACCTCGGTGATTTAATTATCGGGGAGTTATCCTTTGATGCGACGAC
CGACACCTTTGCCGTACATTACACCAAGCACTGGCAGCAAAGCGGATTTCCACTATCCCCAACAATTCCCTTAGATGGCA
CAGGAAGTAGCAGTCAGATATCGATGTTTTTGGTTAACTTATTACCGGAAAACAAAGGATTAGATTATCTAATTGAATCG
CTTGGCGTCTCCAAGGGAAATACCTTTGCCTTGATCCGAGCCATTGGTCTCGATACCGCAGGTGCTGTTGCTTTTGTTCC
TAAAGGGACTTTGCTGCCTGAAACACAATTACGGCCAATTAAGGCTGAAGAAGTTATTCAGCGAATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCTCGACTGTCGGTTGCGGGTGTGCAACCTAAATTAAACCTGTTTTATAAC
GGTGAAGAATTTGCATTTGCCGAAGGCGCACTGTCATCTACCCATATTGTTAAATTCGAAAAATATCGCCATTTAGTGCT
CAATGAATTTATGACGATGCGCTTAGCCAAGGCGATTGGAATGAATGTGGCTAATGTTGATATCGTTCATTTTGGAGATT
ACAAAGTACTCTGTGTCGAACGCTTTGACCGACGTTATATGCCAAATGAGCAAAGGGTATTAAGAAGGCATATTGTCGAT
AGCTGCCAAGCACTTGGTTTTAGTGTTAGCAAAAAATATGAACGTAATTTTGGTTCAGGGCGTGATGTTAAAGATATTCG
TGAAGGGGTAAGTTTTAACAGGCTCTTTAGTCTTGCTGTAAAATGTCGCAATCCAGTGGCTGCTAAGCAAGACATGTTGC
AATGGGCGCTGTTCAATTTACTAACCGGCAATGCCGATGCACACGGTAAAAACTATTCATTTTTTATGACGCCAAGCGGA
ATGGAGCCAACTCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAGGATTTTGAACAACAGCTTGCGATGGCAATCGA
TGACGAATTTGATCCAAACAGCATTTACGCGTATCAATTGGCCGCATTTATTGATGGCTTAGGTTTACCAAGAAATCTAT
TAATCAGTAACTTAACGTCAATAGCGCAAAGAATACCGCAGGCAATAGCGGAGGTGGTTTCAATGCTCCCAGCTCTCGAT
GAGAGTGAAACAGTATTTGTGGCTCATTACAAAGCGCAGTTGCTGGCGAGATGTGATCGTTACCTTAGTTTTGCCGCCGA
GGTCAGGGATGTCAAAGTGTAG

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT217087 WP_004936539.1 NZ_CP083690:4117087-4117296 [Serratia sp. HRI]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT217087 NZ_CP113808:1216225-1216461 [Shewanella sp. DAU305]
ATGGCATCACCGCTAAATCAACAATCCCTCGGTTTGTTAATTAAAGAGCGAAGGAAAAGTGCTGCTCTTACTCAAGACGT
GGCGGCCATGCTGTGTGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAAGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATTCTTGATGGTCTGGGGATTGATATCGTTGCGGCTCAAACCAGCGACACCGAAACTAACGGCTGGTATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References