Detailed information of TA system TA217086

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 4025071..4025727
• Replicon: chromosome
• Accession: NZ_CP083690
• Organism: Serratia sp. HRI

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A5C7DE55
• Locus tag: GF111_RS19290
• Protein ID: WP_047730091.1
• Coordinates: 4025338..4025727 (+)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8G2LCA8
• Locus tag: GF111_RS19285
• Protein ID: WP_004941563.1
• Coordinates: 4025071..4025334 (+)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GF111_RS19270 (GF111_19270)	4021367..4022272	-	906	WP_038873764.1	lipid kinase YegS	-
GF111_RS19275 (GF111_19275)	4022740..4024092	-	1353	WP_038873761.1	tRNA 5-hydroxyuridine modification protein YegQ	-
GF111_RS19280 (GF111_19280)	4024394..4024732	-	339	WP_038873760.1	YegP family protein	-
GF111_RS19285 (GF111_19285)	4025071..4025334	+	264	WP_004941563.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GF111_RS19290 (GF111_19290)	4025338..4025727	+	390	WP_047730091.1	type II toxin-antitoxin system VapC family toxin	Toxin
GF111_RS19295 (GF111_19295)	4025732..4026448	-	717	WP_047730092.1	two-component system response regulator BaeR	-
GF111_RS19300 (GF111_19300)	4026458..4027831	-	1374	WP_060434510.1	two-component system sensor histidine kinase BaeS	-
GF111_RS19305 (GF111_19305)	4027828..4029258	-	1431	WP_047730094.1	MFS transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14337.57 Da
• Isoelectric Point: 7.8794

>T217086 WP_047730091.1 NZ_CP083690:4025338-4025727 [Serratia sp. HRI]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T217086 NZ_CP113808:924626-925933 [Shewanella sp. DAU305]
ATGGCAGTGCTTGATGTTTATATGAATGGCTACCTTGTGGGTGAATTGACCAAATCATCCACAGGCTCTCATCAGTTTGC
GTATGCCCAGCAATGGCTAGCGATACCCGGTAGTCGCCCAATTTCTTTGTCTATGCCGCTACGCAAGCAAGCCTATAAAG
GTGATGAAGTTTATAACTTCTTCGATAATTTGCTACCTGATAATCACGAAGTGAAAAACAGAGTCGTTGCTCGTCATAAT
GCTGATTCGACACAAGCGTTTGACTTACTGGCTAAAATTGGTCAAGACAGTGTGGGTGCATTACAGCTTGTCCCCCATGG
TCAGCCCCCCTTTGATACCAAAAAAATTGAGTCTAAACCGCTATCCGATAAGCAGTTGGAAAAAGTACTCAAGGGTTATC
AGTCCAATATCCCCTTAGGCATGCTAGCCGATGACGATGACTTTAGGATTTCTATTGCCGGTGCCCAAGAAAAGACGGCA
TTACTGAAACTCAATGGAGAGTGGCGATTACCTATCAAATCGACACCCACTACCCATATCATTAAGCTGCCCATAGGTGA
AATAAACAGCCACTCCCACAGCATAGATATGTCAGACAGTGTCGAGAATGAATACCTGTGCATGATGATAGTCAGAGAGT
TTGGTTTAGATGCACCCCAGTGCTCAATAATCAAAGTGGGTGATATTAAAGCGCTTGCTGTGGAGCGATTCGATCGCAGG
CTCTCTTCAGATGGCACATGGATTATGCGGCTGCCCCAAGAGGACTTTTGTCAGGCATTAAATATTCCACCAGCGAAGAA
ATATGAGAGCCTTGGTGGCCCGGGTATTGAACAAATTATGCCTTATCTATTGGGTTCGATGAACTCGGAGCGCGACAGAT
ATAACTTCATCAAGTCTCAGGTTTTGTTTTGGCTTTTAGCCGCAACCGATGGTCATGCTAAAAACTTCTCACTCTTCATC
GAGGCCGATGGCGGATATCGACTAACGCCTTTTTACGATATTTTATCCATGTACCCTGTTATTGGTGGTAAAGGCTTAAA
TATTCGTGATGCCAAGCTCGCTATGGGCCTCAAAGCGGCTAAGGGTAAGAAGTATCAAATCAATCAAATTTTTCCACGGC
ACTTTATCCTAACAGCTAAAGCTGTGGGCTTTGATACTGGGATTATGATGGAGATGATGCGCGACATTGCTGACAAGGTA
GAGGCTGTGGTTGTTAAGGTTAAAGCGCAGCTGCCAGATGATTTTCCACCACACATACAGGATTCAATATTGAACGGTTT
AACTGACAGAATTAAGCGTATAGCTTAG

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 4.6702

>AT217086 WP_004941563.1 NZ_CP083690:4025071-4025334 [Serratia sp. HRI]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT217086 NZ_CP113808:924345-924626 [Shewanella sp. DAU305]
ATGAAGGTGACCAACGCAAAGCAGTTGAGTACGTATCTAAAAGATGCGCGGCTGAACGCGCAGCTCTCGCAAAGCAAGGT
GGCGAGCAAGGTAGGTATTCGCCAGGATACCGTTTCAAGCTTTGAGTTGAATCCGGATTCGACCAAATTAGAAACGCTGT
TTAAGATCCTTTCTGCATTAAACCTAGAGCTAGATATAAAGGTTCGGAATCTACAGCTGGTGGATGAGCGCCGCCATGAT
AACGCCACAGTGCCTGAGCAAGAATGGAAGGAGGAGTGGTAA

Structures

Toxin

• AlphaFold DB: A0A5C7DE55