Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 4025071..4025727 Replicon chromosome
Accession NZ_CP083690
Organism Serratia sp. HRI

Toxin (Protein)


Gene name vapC Uniprot ID A0A5C7DE55
Locus tag GF111_RS19290 Protein ID WP_047730091.1
Coordinates 4025338..4025727 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag GF111_RS19285 Protein ID WP_004941563.1
Coordinates 4025071..4025334 (+) Length 88 a.a.

Genomic Context

GF111_RS19285GF111_RS19290GF111_RS19270GF111_RS19275GF111_RS19280GF111_RS19295GF111_RS19300GF111_RS19305
Location: 4025071..4025334 (264 bp)
Type: Antitoxin
Protein ID: WP_004941563.1
Location: 4025338..4025727 (390 bp)
Type: Toxin
Protein ID: WP_047730091.1
Location: 4021367..4022272 (906 bp)
Type: Others
Protein ID: WP_038873764.1
Location: 4022740..4024092 (1353 bp)
Type: Others
Protein ID: WP_038873761.1
Location: 4024394..4024732 (339 bp)
Type: Others
Protein ID: WP_038873760.1
Location: 4025732..4026448 (717 bp)
Type: Others
Protein ID: WP_047730092.1
Location: 4026458..4027831 (1374 bp)
Type: Others
Protein ID: WP_060434510.1
Location: 4027828..4029258 (1431 bp)
Type: Others
Protein ID: WP_047730094.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GF111_RS19270 (GF111_19270)4021367..4022272-906WP_038873764.1lipid kinase YegS-
GF111_RS19275 (GF111_19275)4022740..4024092-1353WP_038873761.1tRNA 5-hydroxyuridine modification protein YegQ-
GF111_RS19280 (GF111_19280)4024394..4024732-339WP_038873760.1YegP family protein-
GF111_RS19285 (GF111_19285)4025071..4025334+264WP_004941563.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
GF111_RS19290 (GF111_19290)4025338..4025727+390WP_047730091.1type II toxin-antitoxin system VapC family toxinToxin
GF111_RS19295 (GF111_19295)4025732..4026448-717WP_047730092.1two-component system response regulator BaeR-
GF111_RS19300 (GF111_19300)4026458..4027831-1374WP_060434510.1two-component system sensor histidine kinase BaeS-
GF111_RS19305 (GF111_19305)4027828..4029258-1431WP_047730094.1MFS transporter-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14337.57 Da        Isoelectric Point: 7.8794

>T217086 WP_047730091.1 NZ_CP083690:4025338-4025727 [Serratia sp. HRI]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T217086 NZ_CP113808:924626-925933 [Shewanella sp. DAU305]
ATGGCAGTGCTTGATGTTTATATGAATGGCTACCTTGTGGGTGAATTGACCAAATCATCCACAGGCTCTCATCAGTTTGC
GTATGCCCAGCAATGGCTAGCGATACCCGGTAGTCGCCCAATTTCTTTGTCTATGCCGCTACGCAAGCAAGCCTATAAAG
GTGATGAAGTTTATAACTTCTTCGATAATTTGCTACCTGATAATCACGAAGTGAAAAACAGAGTCGTTGCTCGTCATAAT
GCTGATTCGACACAAGCGTTTGACTTACTGGCTAAAATTGGTCAAGACAGTGTGGGTGCATTACAGCTTGTCCCCCATGG
TCAGCCCCCCTTTGATACCAAAAAAATTGAGTCTAAACCGCTATCCGATAAGCAGTTGGAAAAAGTACTCAAGGGTTATC
AGTCCAATATCCCCTTAGGCATGCTAGCCGATGACGATGACTTTAGGATTTCTATTGCCGGTGCCCAAGAAAAGACGGCA
TTACTGAAACTCAATGGAGAGTGGCGATTACCTATCAAATCGACACCCACTACCCATATCATTAAGCTGCCCATAGGTGA
AATAAACAGCCACTCCCACAGCATAGATATGTCAGACAGTGTCGAGAATGAATACCTGTGCATGATGATAGTCAGAGAGT
TTGGTTTAGATGCACCCCAGTGCTCAATAATCAAAGTGGGTGATATTAAAGCGCTTGCTGTGGAGCGATTCGATCGCAGG
CTCTCTTCAGATGGCACATGGATTATGCGGCTGCCCCAAGAGGACTTTTGTCAGGCATTAAATATTCCACCAGCGAAGAA
ATATGAGAGCCTTGGTGGCCCGGGTATTGAACAAATTATGCCTTATCTATTGGGTTCGATGAACTCGGAGCGCGACAGAT
ATAACTTCATCAAGTCTCAGGTTTTGTTTTGGCTTTTAGCCGCAACCGATGGTCATGCTAAAAACTTCTCACTCTTCATC
GAGGCCGATGGCGGATATCGACTAACGCCTTTTTACGATATTTTATCCATGTACCCTGTTATTGGTGGTAAAGGCTTAAA
TATTCGTGATGCCAAGCTCGCTATGGGCCTCAAAGCGGCTAAGGGTAAGAAGTATCAAATCAATCAAATTTTTCCACGGC
ACTTTATCCTAACAGCTAAAGCTGTGGGCTTTGATACTGGGATTATGATGGAGATGATGCGCGACATTGCTGACAAGGTA
GAGGCTGTGGTTGTTAAGGTTAAAGCGCAGCTGCCAGATGATTTTCCACCACACATACAGGATTCAATATTGAACGGTTT
AACTGACAGAATTAAGCGTATAGCTTAG

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT217086 WP_004941563.1 NZ_CP083690:4025071-4025334 [Serratia sp. HRI]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT217086 NZ_CP113808:924345-924626 [Shewanella sp. DAU305]
ATGAAGGTGACCAACGCAAAGCAGTTGAGTACGTATCTAAAAGATGCGCGGCTGAACGCGCAGCTCTCGCAAAGCAAGGT
GGCGAGCAAGGTAGGTATTCGCCAGGATACCGTTTCAAGCTTTGAGTTGAATCCGGATTCGACCAAATTAGAAACGCTGT
TTAAGATCCTTTCTGCATTAAACCTAGAGCTAGATATAAAGGTTCGGAATCTACAGCTGGTGGATGAGCGCCGCCATGAT
AACGCCACAGTGCCTGAGCAAGAATGGAAGGAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5C7DE55

Antitoxin

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Source
ID
Structure
No matching records found

References