Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3632370..3633039 Replicon chromosome
Accession NZ_CP083690
Organism Serratia sp. HRI

Toxin (Protein)


Gene name cptA Uniprot ID A0A5P6GZ53
Locus tag GF111_RS17395 Protein ID WP_047729923.1
Coordinates 3632617..3633039 (+) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8B4GS04
Locus tag GF111_RS17390 Protein ID WP_019455657.1
Coordinates 3632370..3632636 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GF111_RS17365 (GF111_17365) 3627945..3628871 + 927 WP_047729921.1 ribokinase -
GF111_RS17370 (GF111_17370) 3628904..3629512 - 609 WP_025304127.1 HD domain-containing protein -
GF111_RS17375 (GF111_17375) 3629696..3630370 + 675 WP_038871224.1 hemolysin III family protein -
GF111_RS17380 (GF111_17380) 3630521..3631018 + 498 WP_038871226.1 DUF2165 domain-containing protein -
GF111_RS17385 (GF111_17385) 3631057..3632049 - 993 WP_147190254.1 tRNA-modifying protein YgfZ -
GF111_RS17390 (GF111_17390) 3632370..3632636 + 267 WP_019455657.1 FAD assembly factor SdhE Antitoxin
GF111_RS17395 (GF111_17395) 3632617..3633039 + 423 WP_047729923.1 protein YgfX Toxin
GF111_RS17400 (GF111_17400) 3633039..3633734 + 696 WP_055316660.1 two-component system response regulator CreB -
GF111_RS17405 (GF111_17405) 3633731..3635149 + 1419 WP_102779448.1 two-component system sensor histidine kinase CreC -
GF111_RS17410 (GF111_17410) 3635230..3636594 + 1365 WP_055312418.1 cell envelope integrity protein CreD -
GF111_RS17415 (GF111_17415) 3636631..3637149 - 519 WP_038871234.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16500.57 Da        Isoelectric Point: 10.8114

>T217084 WP_047729923.1 NZ_CP083690:3632617-3633039 [Serratia sp. HRI]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPVGDGEEA

Download         Length: 423 bp

>T217084 NZ_CP113799:354150-354527 [Rhodococcus pyridinivorans]
GTGACGTTCTACCTCGACCGCGACGACCTTCTGACGATCGCTGCGCGTGTCAACGGCGGATCGCCCGCTGTGCGCGAGAT
GGGCCTGCTCGACGCAGCGATCGCACGTCCGCAGAGCACCGTGTTCGGTGTCGACGCCTATCCCACACTGTTCGAGAAGG
CAGCCGCGTTGCTCCATTCGATCGCCCGAAACCACGCCCTCGTCGACGGCAACAAGCGGACCGCCTGGGCCGCGACATGG
CTGTTCCTCGGCTACAACGGCATCCGCCTGCAGCGCGGCTTCGACGTGGACGCCGCCGAGGCCCTGATGAATGACACCGC
CACCGGCGCTCACGACGTCGCCTCGATCGCCGCCTCCCTCGCCAAGTTCACGGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10417.91 Da        Isoelectric Point: 4.7921

>AT217084 WP_019455657.1 NZ_CP083690:3632370-3632636 [Serratia sp. HRI]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT217084 NZ_CP113799:353956-354153 [Rhodococcus pyridinivorans]
ATGCCCGGACTCAACATCCAGTTCACCGACGACGAGCAGGCACTGATCCGCGACGCCGCTGATCGCGAGGGGATCTCCCT
CAAAGCGTTCGTGCACAACGCCTCGCTCGACGCTGCCAGCAGCCGTAAACACCTGCGCGACGAGTTGCTCGCCGACATCT
TCGACAAGTCCGCCGAACTCAACGACCGACTCGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5P6GZ53

Antitoxin

Source ID Structure
AlphaFold DB A0A8B4GS04

References