Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2652539..2653140 Replicon chromosome
Accession NZ_CP083690
Organism Serratia sp. HRI

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GF111_RS12775 Protein ID WP_055317375.1
Coordinates 2652760..2653140 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0G3SPC0
Locus tag GF111_RS12770 Protein ID WP_038875999.1
Coordinates 2652539..2652760 (+) Length 74 a.a.

Genomic Context

GF111_RS12750GF111_RS12760GF111_RS12765GF111_RS12770GF111_RS12775GF111_RS12795GF111_RS12755GF111_RS12780GF111_RS12785GF111_RS12790GF111_RS12800
Location: 2647688..2648665 (978 bp)
Type: Others
Protein ID: WP_055317377.1
Location: 2649015..2651078 (2064 bp)
Type: Others
Protein ID: WP_038875997.1
Location: 2651214..2652464 (1251 bp)
Type: Others
Protein ID: WP_004933935.1
Location: 2652539..2652760 (222 bp)
Type: Antitoxin
Protein ID: WP_038875999.1
Location: 2652760..2653140 (381 bp)
Type: Toxin
Protein ID: WP_055317375.1
Location: 2656229..2656576 (348 bp)
Type: Others
Protein ID: WP_016929593.1
Location: 2648667..2648819 (153 bp)
Type: Others
Protein ID: WP_168166338.1
Location: 2653151..2654809 (1659 bp)
Type: Others
Protein ID: WP_047729572.1
Location: 2654977..2655405 (429 bp)
Type: Others
Protein ID: WP_147190061.1
Location: 2655506..2655919 (414 bp)
Type: Others
Protein ID: WP_004933919.1
Location: 2656607..2657887 (1281 bp)
Type: Others
Protein ID: WP_147190059.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GF111_RS12750 (GF111_12750)2647688..2648665+978WP_055317377.1glyoxylate/hydroxypyruvate reductase GhrB-
GF111_RS12755 (GF111_12755)2648667..2648819-153WP_168166338.1hypothetical protein-
GF111_RS12760 (GF111_12760)2649015..2651078+2064WP_038875997.1alpha-amylase-
GF111_RS12765 (GF111_12765)2651214..2652464+1251WP_004933935.1valine--pyruvate transaminase-
GF111_RS12770 (GF111_12770)2652539..2652760+222WP_038875999.1ribbon-helix-helix domain-containing proteinAntitoxin
GF111_RS12775 (GF111_12775)2652760..2653140+381WP_055317375.1type II toxin-antitoxin system VapC family toxinToxin
GF111_RS12780 (GF111_12780)2653151..2654809-1659WP_047729572.1putative transporter-
GF111_RS12785 (GF111_12785)2654977..2655405-429WP_147190061.1small heat shock chaperone IbpB-
GF111_RS12790 (GF111_12790)2655506..2655919-414WP_004933919.1small heat shock chaperone IbpA-
GF111_RS12795 (GF111_12795)2656229..2656576+348WP_016929593.1YceK/YidQ family lipoprotein-
GF111_RS12800 (GF111_12800)2656607..2657887-1281WP_147190059.1DUF3748 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-102)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-40)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14215.56 Da        Isoelectric Point: 7.3170

>T217083 WP_055317375.1 NZ_CP083690:2652760-2653140 [Serratia sp. HRI]
MVAQRALFDTNILIDYLNGIPQAKDVLTEYHINPAISAITWMEVMVGAKKQGPTLELKTRQFLGQFLLLPITDEVAERAV
ELRHSQHVKLPDAIIWATAQVGFRTLISRNPKDFGTDNGVLMPYRL

Download         Length: 381 bp

>T217083 NZ_CP113799:c352327-352070 [Rhodococcus pyridinivorans]
GTGAAAACGATGAGTTACACCGAATCGCGGGCACGCTACGCCGAGGTCCTCGACGCAGTGACCAATGACCGCGAGGAAGT
CATCATCACCCGTGCCGGCCACGAACCCGTGGTCATGGTCTCCCTCGATGATTACGAGTCCCTCCGGGAGACCGCGCACC
TGATGCGCTCCCCCGCCAACGCTCGTCGCCTCTTGGACGCAATGGAGAGGCTCGAAGCCGGTCGCGGCCAGTCGCACAGC
CTGCTCGACGTCGACTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8563.50 Da        Isoelectric Point: 4.4791

>AT217083 WP_038875999.1 NZ_CP083690:2652539-2652760 [Serratia sp. HRI]
MTRIVIDLPEEDLRQLDNLKNIRHVPRAEIIRQAVSRYLAENHVEDPSNAFGLWSGAMGDGVDYENRQREEWE

Download         Length: 222 bp

>AT217083 NZ_CP113799:c352068-351811 [Rhodococcus pyridinivorans]
ATGCTGTTGGTGTGGGACGAGAACGCCTGGCAGGACTACCTTTGGTGGCAACAACAGGACCGAAAGATCCTCAAGAGGAT
CAATACCCTACTGGTCGATATCCAGCGCAATGGCAATGAGGGAATCGGCAAACCCGAACCTCTCAAGTACGACTTCGCCG
GGTATTGGTCCAGACGAATCACCGACGAGCACCGGCTTGTTTACAAGGTGACCGACACGGAGGTCCGCATCGCCGCCTGT
CGGTACCACTACGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0G3SPC0

References