Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2610701..2611236 Replicon chromosome
Accession NZ_CP083690
Organism Serratia sp. HRI

Toxin (Protein)


Gene name relE Uniprot ID A0A854J4R0
Locus tag GF111_RS12590 Protein ID WP_038875945.1
Coordinates 2610701..2610976 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A255NGR4
Locus tag GF111_RS12595 Protein ID WP_047729547.1
Coordinates 2610976..2611236 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GF111_RS12570 (GF111_12570) 2606520..2607512 - 993 WP_047729540.1 acyltransferase -
GF111_RS12575 (GF111_12575) 2607730..2608977 + 1248 WP_038875940.1 MFS transporter -
GF111_RS12580 (GF111_12580) 2609030..2609656 - 627 WP_102779852.1 LysE family translocator -
GF111_RS12585 (GF111_12585) 2609778..2610689 + 912 WP_055311811.1 LysR family transcriptional regulator -
GF111_RS12590 (GF111_12590) 2610701..2610976 - 276 WP_038875945.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GF111_RS12595 (GF111_12595) 2610976..2611236 - 261 WP_047729547.1 ribbon-helix-helix domain-containing protein Antitoxin
GF111_RS12600 (GF111_12600) 2611319..2613160 - 1842 WP_047729548.1 selenocysteine-specific translation elongation factor -
GF111_RS12605 (GF111_12605) 2613157..2614551 - 1395 WP_047729550.1 L-seryl-tRNA(Sec) selenium transferase -
GF111_RS12610 (GF111_12610) 2614620..2615225 - 606 WP_038875954.1 glutathione S-transferase -
GF111_RS12615 (GF111_12615) 2615266..2615916 - 651 WP_047729554.1 DcrB-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10548.34 Da        Isoelectric Point: 10.6099

>T217082 WP_038875945.1 NZ_CP083690:c2610976-2610701 [Serratia sp. HRI]
MALKWTSKALSDLARLFEFLALANRTVAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T217082 NZ_CP113799:c352068-351811 [Rhodococcus pyridinivorans]
ATGCTGTTGGTGTGGGACGAGAACGCCTGGCAGGACTACCTTTGGTGGCAACAACAGGACCGAAAGATCCTCAAGAGGAT
CAATACCCTACTGGTCGATATCCAGCGCAATGGCAATGAGGGAATCGGCAAACCCGAACCTCTCAAGTACGACTTCGCCG
GGTATTGGTCCAGACGAATCACCGACGAGCACCGGCTTGTTTACAAGGTGACCGACACGGAGGTCCGCATCGCCGCCTGT
CGGTACCACTACGGATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9696.04 Da        Isoelectric Point: 4.5201

>AT217082 WP_047729547.1 NZ_CP083690:c2611236-2610976 [Serratia sp. HRI]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALVDVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT217082 NZ_CP113799:c352327-352070 [Rhodococcus pyridinivorans]
GTGAAAACGATGAGTTACACCGAATCGCGGGCACGCTACGCCGAGGTCCTCGACGCAGTGACCAATGACCGCGAGGAAGT
CATCATCACCCGTGCCGGCCACGAACCCGTGGTCATGGTCTCCCTCGATGATTACGAGTCCCTCCGGGAGACCGCGCACC
TGATGCGCTCCCCCGCCAACGCTCGTCGCCTCTTGGACGCAATGGAGAGGCTCGAAGCCGGTCGCGGCCAGTCGCACAGC
CTGCTCGACGTCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854J4R0

Antitoxin

Source ID Structure
AlphaFold DB A0A255NGR4

References