Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2610701..2611236 Replicon chromosome
Accession NZ_CP083690
Organism Serratia sp. HRI

Toxin (Protein)


Gene name relE Uniprot ID A0A854J4R0
Locus tag GF111_RS12590 Protein ID WP_038875945.1
Coordinates 2610701..2610976 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A255NGR4
Locus tag GF111_RS12595 Protein ID WP_047729547.1
Coordinates 2610976..2611236 (-) Length 87 a.a.

Genomic Context

GF111_RS12575GF111_RS12585GF111_RS12570GF111_RS12580GF111_RS12590GF111_RS12595GF111_RS12600GF111_RS12605GF111_RS12610GF111_RS12615
Location: 2607730..2608977 (1248 bp)
Type: Others
Protein ID: WP_038875940.1
Location: 2609778..2610689 (912 bp)
Type: Others
Protein ID: WP_055311811.1
Location: 2606520..2607512 (993 bp)
Type: Others
Protein ID: WP_047729540.1
Location: 2609030..2609656 (627 bp)
Type: Others
Protein ID: WP_102779852.1
Location: 2610701..2610976 (276 bp)
Type: Toxin
Protein ID: WP_038875945.1
Location: 2610976..2611236 (261 bp)
Type: Antitoxin
Protein ID: WP_047729547.1
Location: 2611319..2613160 (1842 bp)
Type: Others
Protein ID: WP_047729548.1
Location: 2613157..2614551 (1395 bp)
Type: Others
Protein ID: WP_047729550.1
Location: 2614620..2615225 (606 bp)
Type: Others
Protein ID: WP_038875954.1
Location: 2615266..2615916 (651 bp)
Type: Others
Protein ID: WP_047729554.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GF111_RS12570 (GF111_12570)2606520..2607512-993WP_047729540.1acyltransferase-
GF111_RS12575 (GF111_12575)2607730..2608977+1248WP_038875940.1MFS transporter-
GF111_RS12580 (GF111_12580)2609030..2609656-627WP_102779852.1LysE family translocator-
GF111_RS12585 (GF111_12585)2609778..2610689+912WP_055311811.1LysR family transcriptional regulator-
GF111_RS12590 (GF111_12590)2610701..2610976-276WP_038875945.1type II toxin-antitoxin system RelE/ParE family toxinToxin
GF111_RS12595 (GF111_12595)2610976..2611236-261WP_047729547.1ribbon-helix-helix domain-containing proteinAntitoxin
GF111_RS12600 (GF111_12600)2611319..2613160-1842WP_047729548.1selenocysteine-specific translation elongation factor-
GF111_RS12605 (GF111_12605)2613157..2614551-1395WP_047729550.1L-seryl-tRNA(Sec) selenium transferase-
GF111_RS12610 (GF111_12610)2614620..2615225-606WP_038875954.1glutathione S-transferase-
GF111_RS12615 (GF111_12615)2615266..2615916-651WP_047729554.1DcrB-related protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10548.34 Da        Isoelectric Point: 10.6099

>T217082 WP_038875945.1 NZ_CP083690:c2610976-2610701 [Serratia sp. HRI]
MALKWTSKALSDLARLFEFLALANRTVAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T217082 NZ_CP113799:c352068-351811 [Rhodococcus pyridinivorans]
ATGCTGTTGGTGTGGGACGAGAACGCCTGGCAGGACTACCTTTGGTGGCAACAACAGGACCGAAAGATCCTCAAGAGGAT
CAATACCCTACTGGTCGATATCCAGCGCAATGGCAATGAGGGAATCGGCAAACCCGAACCTCTCAAGTACGACTTCGCCG
GGTATTGGTCCAGACGAATCACCGACGAGCACCGGCTTGTTTACAAGGTGACCGACACGGAGGTCCGCATCGCCGCCTGT
CGGTACCACTACGGATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9696.04 Da        Isoelectric Point: 4.5201

>AT217082 WP_047729547.1 NZ_CP083690:c2611236-2610976 [Serratia sp. HRI]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALVDVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT217082 NZ_CP113799:c352327-352070 [Rhodococcus pyridinivorans]
GTGAAAACGATGAGTTACACCGAATCGCGGGCACGCTACGCCGAGGTCCTCGACGCAGTGACCAATGACCGCGAGGAAGT
CATCATCACCCGTGCCGGCCACGAACCCGTGGTCATGGTCTCCCTCGATGATTACGAGTCCCTCCGGGAGACCGCGCACC
TGATGCGCTCCCCCGCCAACGCTCGTCGCCTCTTGGACGCAATGGAGAGGCTCGAAGCCGGTCGCGGCCAGTCGCACAGC
CTGCTCGACGTCGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A854J4R0

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A255NGR4

References