Detailed information of TA system TA217081

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 2578470..2579232
• Replicon: chromosome
• Accession: NZ_CP083690
• Organism: Serratia sp. HRI

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: GF111_RS12415
• Protein ID: WP_147191515.1
• Coordinates: 2578470..2578838 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: GF111_RS12420
• Protein ID: WP_224217841.1
• Coordinates: 2578897..2579232 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GF111_RS12390 (GF111_12390)	2573566..2574732	-	1167	WP_148940397.1	MFS transporter	-
GF111_RS12395 (GF111_12395)	2574907..2575650	-	744	WP_224217840.1	nucleotidyltransferase domain-containing protein	-
GF111_RS12400 (GF111_12400)	2575652..2576164	-	513	WP_147191915.1	DUF962 domain-containing protein	-
GF111_RS12405 (GF111_12405)	2576371..2577414	-	1044	WP_047729502.1	virulence RhuM family protein	-
GF111_RS12410 (GF111_12410)	2577504..2578337	-	834	Protein_2410	DUF4942 domain-containing protein	-
GF111_RS12415 (GF111_12415)	2578470..2578838	-	369	WP_147191515.1	TA system toxin CbtA family protein	Toxin
GF111_RS12420 (GF111_12420)	2578897..2579232	-	336	WP_224217841.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
GF111_RS12425 (GF111_12425)	2579244..2579723	-	480	WP_047729511.1	DNA repair protein RadC	-
GF111_RS12430 (GF111_12430)	2579905..2580525	-	621	WP_047730810.1	hypothetical protein	-
GF111_RS12435 (GF111_12435)	2580553..2581107	-	555	WP_047729513.1	hypothetical protein	-
GF111_RS12440 (GF111_12440)	2581355..2582236	-	882	WP_224217842.1	50S ribosome-binding GTPase	-
GF111_RS12445 (GF111_12445)	2582319..2583125	-	807	WP_047729515.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2578470..2599474	21004

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (8-106)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13449.48 Da
• Isoelectric Point: 7.8575

>T217081 WP_147191515.1 NZ_CP083690:c2578838-2578470 [Serratia sp. HRI]
MRTIPASSTRAAPSCPSPMAIWQFLLTYLLAQHYGLTLNDTAFSDDAVIQAHIGDGISLADTLNAMVEKFDLVRIDRRGF
DCQAQSPFITAIDILRARRATGLMTRMGYQTITSVIRGEKQA

Nucleotide

• Length: 369 bp

>T217081 NZ_CP113799:c343843-343562 [Rhodococcus pyridinivorans]
GTGATCGAATCGTTCGCCGACAAAGAGACCGAGCGAGTCTTTCACCGGCAGTTCTCCAAAAAACTCCCACAGGACATTCA
GCGGATCGCACGCCGGCGACTGCTGCTGGTCGACGCGGCTACCGATATCAACGATCTGCGGGTACCTCCGGGTAACCGCC
TGGAGAAGCTCGCCGGGGACCGCGCGGGCCAGTACAGCGTTCGGATCAACGACCAGTACCGCATCTGCTTCACCTGGCGC
ACCACAGCCGCATACAACGTAGAAATCACCGACTACCACTGA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12443.11 Da
• Isoelectric Point: 5.0211

>AT217081 WP_224217841.1 NZ_CP083690:c2579232-2578897 [Serratia sp. HRI]
MPSIIAPVWGLKRNVTPQFGARLVQEGGRLHFLADRADISGTFSDEQLRDVDNAFPQFINHLELMLLSGELNPRYQHCVT
LYCNGLTCEADSLGSQGYVYLSIYPTPETPR

Nucleotide

• Length: 336 bp

>AT217081 NZ_CP113799:c343501-343208 [Rhodococcus pyridinivorans]
ATGACTGCAGACCTGAGCCCCATCCACCCCGGCGAGATCCTCCGTGAGGACTTCCTCGAACCGCTCGGCATCACCCAGAA
CCGCCTTGCCACCACCATCGGTGTCCCCCCACGACGGATCAACGAGATCGTGCACGGAAAACGCTCGATCACCGCAGACA
CCGCACTGCGGCTGGCCAAGGCATTCGGCAACAGCGCACAGTTCTGGCTCAACATCCAGGACCGCTACGAACTCGATATC
GCAGCAGACAAGTTGGGCGACACGCTTGCCGGTATCCATCGGCTCTCGGCATAA