Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 2578470..2579232 Replicon chromosome
Accession NZ_CP083690
Organism Serratia sp. HRI

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag GF111_RS12415 Protein ID WP_147191515.1
Coordinates 2578470..2578838 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag GF111_RS12420 Protein ID WP_224217841.1
Coordinates 2578897..2579232 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GF111_RS12390 (GF111_12390) 2573566..2574732 - 1167 WP_148940397.1 MFS transporter -
GF111_RS12395 (GF111_12395) 2574907..2575650 - 744 WP_224217840.1 nucleotidyltransferase domain-containing protein -
GF111_RS12400 (GF111_12400) 2575652..2576164 - 513 WP_147191915.1 DUF962 domain-containing protein -
GF111_RS12405 (GF111_12405) 2576371..2577414 - 1044 WP_047729502.1 virulence RhuM family protein -
GF111_RS12410 (GF111_12410) 2577504..2578337 - 834 Protein_2410 DUF4942 domain-containing protein -
GF111_RS12415 (GF111_12415) 2578470..2578838 - 369 WP_147191515.1 TA system toxin CbtA family protein Toxin
GF111_RS12420 (GF111_12420) 2578897..2579232 - 336 WP_224217841.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GF111_RS12425 (GF111_12425) 2579244..2579723 - 480 WP_047729511.1 DNA repair protein RadC -
GF111_RS12430 (GF111_12430) 2579905..2580525 - 621 WP_047730810.1 hypothetical protein -
GF111_RS12435 (GF111_12435) 2580553..2581107 - 555 WP_047729513.1 hypothetical protein -
GF111_RS12440 (GF111_12440) 2581355..2582236 - 882 WP_224217842.1 50S ribosome-binding GTPase -
GF111_RS12445 (GF111_12445) 2582319..2583125 - 807 WP_047729515.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2578470..2599474 21004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-111)

Antitoxin

Antitoxin CbeA

(8-106)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13449.48 Da        Isoelectric Point: 7.8575

>T217081 WP_147191515.1 NZ_CP083690:c2578838-2578470 [Serratia sp. HRI]
MRTIPASSTRAAPSCPSPMAIWQFLLTYLLAQHYGLTLNDTAFSDDAVIQAHIGDGISLADTLNAMVEKFDLVRIDRRGF
DCQAQSPFITAIDILRARRATGLMTRMGYQTITSVIRGEKQA

Download         Length: 369 bp

>T217081 NZ_CP113799:c343843-343562 [Rhodococcus pyridinivorans]
GTGATCGAATCGTTCGCCGACAAAGAGACCGAGCGAGTCTTTCACCGGCAGTTCTCCAAAAAACTCCCACAGGACATTCA
GCGGATCGCACGCCGGCGACTGCTGCTGGTCGACGCGGCTACCGATATCAACGATCTGCGGGTACCTCCGGGTAACCGCC
TGGAGAAGCTCGCCGGGGACCGCGCGGGCCAGTACAGCGTTCGGATCAACGACCAGTACCGCATCTGCTTCACCTGGCGC
ACCACAGCCGCATACAACGTAGAAATCACCGACTACCACTGA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12443.11 Da        Isoelectric Point: 5.0211

>AT217081 WP_224217841.1 NZ_CP083690:c2579232-2578897 [Serratia sp. HRI]
MPSIIAPVWGLKRNVTPQFGARLVQEGGRLHFLADRADISGTFSDEQLRDVDNAFPQFINHLELMLLSGELNPRYQHCVT
LYCNGLTCEADSLGSQGYVYLSIYPTPETPR

Download         Length: 336 bp

>AT217081 NZ_CP113799:c343501-343208 [Rhodococcus pyridinivorans]
ATGACTGCAGACCTGAGCCCCATCCACCCCGGCGAGATCCTCCGTGAGGACTTCCTCGAACCGCTCGGCATCACCCAGAA
CCGCCTTGCCACCACCATCGGTGTCCCCCCACGACGGATCAACGAGATCGTGCACGGAAAACGCTCGATCACCGCAGACA
CCGCACTGCGGCTGGCCAAGGCATTCGGCAACAGCGCACAGTTCTGGCTCAACATCCAGGACCGCTACGAACTCGATATC
GCAGCAGACAAGTTGGGCGACACGCTTGCCGGTATCCATCGGCTCTCGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References