Detailed information of TA system TA217080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2472714..2473186
• Replicon: chromosome
• Accession: NZ_CP083690
• Organism: Serratia sp. HRI

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5P6GNV0
• Locus tag: GF111_RS11925
• Protein ID: WP_048232401.1
• Coordinates: 2472714..2472989 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GF111_RS11930
• Protein ID: WP_033649649.1
• Coordinates: 2472989..2473186 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GF111_RS11910 (GF111_11910)	2467757..2468134	-	378	WP_047729408.1	AprI/Inh family metalloprotease inhibitor	-
GF111_RS11915 (GF111_11915)	2468190..2469653	-	1464	WP_038874135.1	serralysin family metalloprotease	-
GF111_RS11920 (GF111_11920)	2470336..2472654	+	2319	WP_048232403.1	zinc/cadmium/mercury/lead-transporting ATPase	-
GF111_RS11925 (GF111_11925)	2472714..2472989	-	276	WP_048232401.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
GF111_RS11930 (GF111_11930)	2472989..2473186	-	198	WP_033649649.1	hypothetical protein	Antitoxin
GF111_RS11935 (GF111_11935)	2473248..2473493	-	246	WP_025304890.1	sulfurtransferase TusA	-
GF111_RS11940 (GF111_11940)	2473714..2474373	+	660	WP_047729415.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
GF111_RS11945 (GF111_11945)	2474425..2474860	+	436	Protein_2325	GNAT family N-acetyltransferase	-
GF111_RS11950 (GF111_11950)	2474941..2475504	+	564	WP_047729417.1	DcrB family lipoprotein	-
GF111_RS11955 (GF111_11955)	2475540..2476739	-	1200	WP_055317090.1	anaerobic glycerol-3-phosphate dehydrogenase subunit GlpC	-
GF111_RS11960 (GF111_11960)	2476736..2478004	-	1269	WP_055313077.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10666.57 Da
• Isoelectric Point: 11.2806

>T217080 WP_048232401.1 NZ_CP083690:c2472989-2472714 [Serratia sp. HRI]
MLNIEWTRVARQDLGEIVGFIANDNPLAARKMKALIMEAVIPAARHPRIFRRGRVDGTHEIPLHPHYLLVYQVLETHIRV
LRVLHTRRQYP

Nucleotide

• Length: 276 bp

>T217080 NZ_CP083690:c2472989-2472714 [Serratia sp. HRI]
ATGCTCAACATCGAATGGACTCGAGTCGCACGTCAGGATCTGGGGGAGATTGTGGGATTTATCGCCAATGATAACCCTCT
GGCGGCCAGAAAAATGAAGGCTCTCATCATGGAGGCCGTCATTCCCGCCGCCAGACATCCTCGAATTTTCCGGCGCGGCA
GAGTGGACGGCACGCATGAAATCCCCCTGCATCCCCATTATCTCCTGGTTTACCAGGTGCTGGAAACTCACATCCGGGTG
TTGCGGGTTTTACATACGCGCCGACAATATCCTTAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7398.49 Da
• Isoelectric Point: 4.4143

>AT217080 WP_033649649.1 NZ_CP083690:c2473186-2472989 [Serratia sp. HRI]
MSILLLPTVAKMENEERTQGYERWFLERVQEAMDEPRPGIPHDDVMAEMDAVIAAAEARIKAKQA

Nucleotide

• Length: 198 bp

>AT217080 NZ_CP083690:c2473186-2472989 [Serratia sp. HRI]
ATGAGTATTTTACTGCTGCCTACGGTTGCCAAGATGGAAAATGAGGAGCGTACACAGGGCTATGAGCGCTGGTTTCTTGA
AAGAGTTCAGGAAGCCATGGATGAGCCACGGCCCGGTATTCCTCATGATGACGTGATGGCTGAAATGGATGCTGTTATCG
CTGCTGCAGAAGCCAGGATCAAAGCGAAGCAGGCATAA

Structures

Toxin

• AlphaFold DB: A0A5P6GNV0