Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2472714..2473186 Replicon chromosome
Accession NZ_CP083690
Organism Serratia sp. HRI

Toxin (Protein)


Gene name relE Uniprot ID A0A5P6GNV0
Locus tag GF111_RS11925 Protein ID WP_048232401.1
Coordinates 2472714..2472989 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag GF111_RS11930 Protein ID WP_033649649.1
Coordinates 2472989..2473186 (-) Length 66 a.a.

Genomic Context

GF111_RS11920GF111_RS11940GF111_RS11945GF111_RS11950GF111_RS11910GF111_RS11915GF111_RS11925GF111_RS11930GF111_RS11935GF111_RS11955GF111_RS11960
Location: 2470336..2472654 (2319 bp)
Type: Others
Protein ID: WP_048232403.1
Location: 2473714..2474373 (660 bp)
Type: Others
Protein ID: WP_047729415.1
Location: 2474425..2474860 (436 bp)
Type: Others
Protein ID: Protein_2325
Location: 2474941..2475504 (564 bp)
Type: Others
Protein ID: WP_047729417.1
Location: 2467757..2468134 (378 bp)
Type: Others
Protein ID: WP_047729408.1
Location: 2468190..2469653 (1464 bp)
Type: Others
Protein ID: WP_038874135.1
Location: 2472714..2472989 (276 bp)
Type: Toxin
Protein ID: WP_048232401.1
Location: 2472989..2473186 (198 bp)
Type: Antitoxin
Protein ID: WP_033649649.1
Location: 2473248..2473493 (246 bp)
Type: Others
Protein ID: WP_025304890.1
Location: 2475540..2476739 (1200 bp)
Type: Others
Protein ID: WP_055317090.1
Location: 2476736..2478004 (1269 bp)
Type: Others
Protein ID: WP_055313077.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GF111_RS11910 (GF111_11910)2467757..2468134-378WP_047729408.1AprI/Inh family metalloprotease inhibitor-
GF111_RS11915 (GF111_11915)2468190..2469653-1464WP_038874135.1serralysin family metalloprotease-
GF111_RS11920 (GF111_11920)2470336..2472654+2319WP_048232403.1zinc/cadmium/mercury/lead-transporting ATPase-
GF111_RS11925 (GF111_11925)2472714..2472989-276WP_048232401.1type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE familyToxin
GF111_RS11930 (GF111_11930)2472989..2473186-198WP_033649649.1hypothetical proteinAntitoxin
GF111_RS11935 (GF111_11935)2473248..2473493-246WP_025304890.1sulfurtransferase TusA-
GF111_RS11940 (GF111_11940)2473714..2474373+660WP_047729415.17-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter-
GF111_RS11945 (GF111_11945)2474425..2474860+436Protein_2325GNAT family N-acetyltransferase-
GF111_RS11950 (GF111_11950)2474941..2475504+564WP_047729417.1DcrB family lipoprotein-
GF111_RS11955 (GF111_11955)2475540..2476739-1200WP_055317090.1anaerobic glycerol-3-phosphate dehydrogenase subunit GlpC-
GF111_RS11960 (GF111_11960)2476736..2478004-1269WP_055313077.1glycerol-3-phosphate dehydrogenase subunit GlpB-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10666.57 Da        Isoelectric Point: 11.2806

>T217080 WP_048232401.1 NZ_CP083690:c2472989-2472714 [Serratia sp. HRI]
MLNIEWTRVARQDLGEIVGFIANDNPLAARKMKALIMEAVIPAARHPRIFRRGRVDGTHEIPLHPHYLLVYQVLETHIRV
LRVLHTRRQYP

Download         Length: 276 bp

>T217080 NZ_CP083690:c2472989-2472714 [Serratia sp. HRI]
ATGCTCAACATCGAATGGACTCGAGTCGCACGTCAGGATCTGGGGGAGATTGTGGGATTTATCGCCAATGATAACCCTCT
GGCGGCCAGAAAAATGAAGGCTCTCATCATGGAGGCCGTCATTCCCGCCGCCAGACATCCTCGAATTTTCCGGCGCGGCA
GAGTGGACGGCACGCATGAAATCCCCCTGCATCCCCATTATCTCCTGGTTTACCAGGTGCTGGAAACTCACATCCGGGTG
TTGCGGGTTTTACATACGCGCCGACAATATCCTTAA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7398.49 Da        Isoelectric Point: 4.4143

>AT217080 WP_033649649.1 NZ_CP083690:c2473186-2472989 [Serratia sp. HRI]
MSILLLPTVAKMENEERTQGYERWFLERVQEAMDEPRPGIPHDDVMAEMDAVIAAAEARIKAKQA

Download         Length: 198 bp

>AT217080 NZ_CP083690:c2473186-2472989 [Serratia sp. HRI]
ATGAGTATTTTACTGCTGCCTACGGTTGCCAAGATGGAAAATGAGGAGCGTACACAGGGCTATGAGCGCTGGTTTCTTGA
AAGAGTTCAGGAAGCCATGGATGAGCCACGGCCCGGTATTCCTCATGATGACGTGATGGCTGAAATGGATGCTGTTATCG
CTGCTGCAGAAGCCAGGATCAAAGCGAAGCAGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A5P6GNV0

Antitoxin

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Source
ID
Structure
No matching records found

References