Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 258139..258785 Replicon chromosome
Accession NC_008391
Organism Burkholderia ambifaria AMMD

Toxin (Protein)


Gene name vapC Uniprot ID Q0BA08
Locus tag BAMB_RS17445 Protein ID WP_011658486.1
Coordinates 258378..258785 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q0BA09
Locus tag BAMB_RS17440 Protein ID WP_011658485.1
Coordinates 258139..258381 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BAMB_RS17425 254138..255544 + 1407 WP_011658482.1 aspartate ammonia-lyase -
BAMB_RS17430 255648..257141 + 1494 WP_011658483.1 amino acid permease -
BAMB_RS17435 257185..257874 - 690 WP_041491430.1 phospholipase -
BAMB_RS17440 258139..258381 + 243 WP_011658485.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
BAMB_RS17445 258378..258785 + 408 WP_011658486.1 type II toxin-antitoxin system VapC family toxin Toxin
BAMB_RS17450 259235..261625 + 2391 WP_011658487.1 MCP four helix bundle domain-containing protein -
BAMB_RS17455 261640..262368 + 729 WP_041491633.1 chemotaxis protein -
BAMB_RS17460 262365..262949 + 585 WP_011658489.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-122)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 14843.92 Da        Isoelectric Point: 6.3323

>T21708 WP_011658486.1 NC_008391:258378-258785 [Burkholderia ambifaria AMMD]
MKFLLDTHAVIAILKGEQAMLARLRRHQPADFGIPAIVAHELYYGAYKSQRAAANLARVEGLQFEVVSFDAEDAQHAGEI
GAQLAAVGTPIGPYDALIAGQARARRLVLVTHNTREFERVPELQVEDWLAAAREN

Download         Length: 408 bp

>T21708 NC_008391:258378-258785 [Burkholderia ambifaria AMMD]
ATGAAGTTTCTGCTGGATACCCATGCGGTAATCGCCATTCTGAAAGGCGAACAGGCCATGCTGGCCCGATTGCGTAGACA
TCAACCTGCGGATTTCGGAATTCCCGCGATCGTCGCGCATGAACTCTATTACGGGGCGTACAAGAGTCAGAGAGCGGCAG
CGAATCTGGCACGCGTCGAGGGGCTTCAGTTCGAGGTCGTGTCGTTCGATGCGGAAGATGCGCAGCATGCCGGTGAAATC
GGTGCGCAACTGGCCGCGGTGGGAACACCGATCGGGCCATACGATGCATTGATCGCAGGACAGGCGCGAGCGCGACGCCT
GGTGCTTGTCACGCACAACACGCGCGAGTTTGAGCGGGTCCCGGAACTGCAGGTCGAGGATTGGCTCGCGGCGGCGCGCG
AAAACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8872.03 Da        Isoelectric Point: 4.7628

>AT21708 WP_011658485.1 NC_008391:258139-258381 [Burkholderia ambifaria AMMD]
METAKIFKHGGSQAVRLPKDFRFDTTEVRIRRHGASVILEPVPQDWAWLTPLIGPVDADFEAAAATEPAAQERPGLDVFE

Download         Length: 243 bp

>AT21708 NC_008391:258139-258381 [Burkholderia ambifaria AMMD]
ATGGAGACTGCCAAGATTTTCAAGCATGGTGGATCGCAGGCCGTCCGCTTGCCGAAGGATTTCCGCTTCGATACCACGGA
GGTCCGGATTCGTCGGCACGGCGCGTCTGTCATTCTCGAACCGGTGCCGCAAGACTGGGCATGGCTGACACCGTTGATCG
GCCCGGTTGACGCCGATTTTGAGGCCGCCGCGGCAACCGAGCCTGCCGCTCAAGAGCGTCCGGGGCTGGACGTGTTTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q0BA08

Antitoxin

Source ID Structure
AlphaFold DB A0A3P0NDJ4

References