Detailed information of TA system TA217079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 2198152..2198723
• Replicon: chromosome
• Accession: NZ_CP083690
• Organism: Serratia sp. HRI

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GF111_RS10615
• Protein ID: WP_147190599.1
• Coordinates: 2198152..2198427 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A086G7I5
• Locus tag: GF111_RS10620
• Protein ID: WP_013811307.1
• Coordinates: 2198436..2198723 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GF111_RS10595 (GF111_10595)	2193585..2194109	-	525	WP_047729213.1	NAD(P)H-dependent oxidoreductase	-
GF111_RS10600 (GF111_10600)	2194216..2195130	+	915	WP_048232521.1	LysR family transcriptional regulator	-
GF111_RS10605 (GF111_10605)	2195375..2197513	+	2139	WP_004933403.1	anaerobic ribonucleoside-triphosphate reductase	-
GF111_RS10610 (GF111_10610)	2197682..2198146	+	465	WP_033636852.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
GF111_RS10615 (GF111_10615)	2198152..2198427	-	276	WP_147190599.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GF111_RS10620 (GF111_10620)	2198436..2198723	-	288	WP_013811307.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GF111_RS10625 (GF111_10625)	2198829..2199884	-	1056	WP_147190601.1	permease	-
GF111_RS10630 (GF111_10630)	2200112..2200840	+	729	WP_015376439.1	phosphonate metabolism transcriptional regulator PhnF	-
GF111_RS10635 (GF111_10635)	2200841..2201284	+	444	WP_019453314.1	phosphonate C-P lyase system protein PhnG	-
GF111_RS10640 (GF111_10640)	2201288..2201869	+	582	WP_147190602.1	phosphonate C-P lyase system protein PhnH	-
GF111_RS10645 (GF111_10645)	2201869..2202954	+	1086	WP_033636846.1	carbon-phosphorus lyase complex subunit PhnI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-70)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10751.49 Da
• Isoelectric Point: 9.5103

>T217079 WP_147190599.1 NZ_CP083690:c2198427-2198152 [Serratia sp. HRI]
MRIEWDNAAQRDRERIFEFLYIFNPQAAVQADNEIDKAVKRLLDHPELGKPWYGKARKLLINKASLLLVYIIVDDVIKVF
SIAHQREKFPN

Nucleotide

• Length: 276 bp

>T217079 NZ_CP113797:c2490812-2490492 [Leptolyngbya sp. PKUAC-SCTA174]
ATGACAACCATTTGGATCGATGCACATCTGTCTCCGGCGATAGCAACCTGGATCACAGATACCTTTGGGATTACAGCGTT
GGCGTTACGGGATCTTAGTCTACGAGATGCAGAAGACCCTGAAATCTTTGAGGCTGCAAAGGCTCAAGGAATAATTTTTA
TGACGAAAGATAGTGATTTTGTAGATTTAGTTGAGCGCTTGGGATCACCACCGCAAATTATCTGGTTGACTTGCGGCAAT
ACCTCAAATGCGAGGCTAAGGGAGATATTGAGTGCAGTTCTACCAGAAACATTAAAGTTACTGCGTTCTGGTGAAAACTA
G

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11032.33 Da
• Isoelectric Point: 5.8001

>AT217079 WP_013811307.1 NZ_CP083690:c2198723-2198436 [Serratia sp. HRI]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Nucleotide

• Length: 288 bp

>AT217079 NZ_CP113797:c2491033-2490809 [Leptolyngbya sp. PKUAC-SCTA174]
ATGTCAAAGCTACTTGAACGAATTACAGTAAATCCCAGGCAATGTGGTGGTCGTCCTTGTATTCGTGGGATGAGAATTCG
AGTGTCTGATGTTTTAGATTTGTTCGCAGCAGGTCTAAGTGCTGAAGAGATTTTAGAAGACTTGCCAGATTTAGAAATGG
ATGATATACGAGCTTCCTTAACATACGCAGCACGTAAATTGAACCATCCTATATTGGTGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A086G7I5