Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1557500..1558122 Replicon chromosome
Accession NZ_CP083690
Organism Serratia sp. HRI

Toxin (Protein)


Gene name Hha Uniprot ID A0A8B4G7F9
Locus tag GF111_RS07625 Protein ID WP_004940313.1
Coordinates 1557919..1558122 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A2X2G5J9
Locus tag GF111_RS07620 Protein ID WP_004940312.1
Coordinates 1557500..1557868 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GF111_RS07590 (GF111_07590) 1553593..1553847 + 255 WP_038874985.1 type B 50S ribosomal protein L31 -
GF111_RS07595 (GF111_07595) 1553860..1554000 + 141 WP_004940304.1 type B 50S ribosomal protein L36 -
GF111_RS07600 (GF111_07600) 1554107..1554985 - 879 WP_038874983.1 zinc ABC transporter substrate-binding protein -
GF111_RS07605 (GF111_07605) 1555011..1555868 - 858 WP_038874980.1 metal ABC transporter permease -
GF111_RS07610 (GF111_07610) 1555865..1556578 - 714 WP_047728664.1 ABC transporter ATP-binding protein -
GF111_RS07615 (GF111_07615) 1556988..1557341 + 354 WP_038874974.1 hypothetical protein -
GF111_RS07620 (GF111_07620) 1557500..1557868 + 369 WP_004940312.1 Hha toxicity modulator TomB Antitoxin
GF111_RS07625 (GF111_07625) 1557919..1558122 + 204 WP_004940313.1 HHA domain-containing protein Toxin
GF111_RS07630 (GF111_07630) 1558406..1558924 - 519 WP_147191842.1 cytochrome b/b6 domain-containing protein -
GF111_RS07635 (GF111_07635) 1558977..1560404 - 1428 WP_055313421.1 N-acetylglucosamine-binding protein GbpA -
GF111_RS07640 (GF111_07640) 1560657..1561019 + 363 WP_147191840.1 type II secretion system pilot lipoprotein GspS -
GF111_RS07645 (GF111_07645) 1561016..1561831 - 816 WP_147191838.1 A24 family peptidase -
GF111_RS07650 (GF111_07650) 1561868..1562314 - 447 WP_047728676.1 type II secretion system protein GspM -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8107.37 Da        Isoelectric Point: 6.9756

>T217078 WP_004940313.1 NZ_CP083690:1557919-1558122 [Serratia sp. HRI]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPTSVWKYVR

Download         Length: 204 bp

>T217078 NZ_CP113797:1707219-1707557 [Leptolyngbya sp. PKUAC-SCTA174]
ATGTATCGGGGAGAAATTTGGTGGGCGAATTTACCCAATCCAGTAGGTTCAGAACCCGGATATCGCCGTCCCGTCTTAGT
GATTCAAGATGATACTTTCACTCAAAGTCGTATTAGAACAATTATTGTTGTCATCATTACCTCAAATGTCCAGTTGGCAG
AAGCGCCGGGCAATGTGCTATTACCTCGTGAGGTATCCGGTTTACCGAGAGATTCCGTTGTAAATATCTCTCAGATTTTC
ACAGTTAATAAAACATTCTTGGTTGAGCGTGTTGGTGCGTTACCCGATTATTTACAGGAGGAGGTAGATGAAGGTTTACG
AACAATTTTGTATCTCTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14261.95 Da        Isoelectric Point: 4.4314

>AT217078 WP_004940312.1 NZ_CP083690:1557500-1557868 [Serratia sp. HRI]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSSVNLQLNELIEHIASFVMSYKIKYMDESDLSELVEEYL
DDTYTLFSSYGINDSDLRRWQKTKARLFRMFSGEDICTTMKT

Download         Length: 369 bp

>AT217078 NZ_CP113797:1706983-1707219 [Leptolyngbya sp. PKUAC-SCTA174]
ATGAAAACTGCGATTTCGCTTCCAGATTCAGTGTTTGAACAGGCGGAAGCACTCGCTCAGCAGTTAGGGTTGTCGCGTAG
CGAGCTTTATACAAAAGCGTTACAGGCGTATTTGAAAAGGTACAACCGCGATCAAATCTTGCTCAAGTTGAACCAAGTTT
ATTCTAGAGAGTCCTCTGAACTTGATCCAGTAATGGCAAGAATGCAGTTTATGTCCTTGCCCCGCGAGGATTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B4G7F9

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2G5J9

References