Detailed information of TA system TA217076

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 858543..859138
• Replicon: chromosome
• Accession: NZ_CP083690
• Organism: Serratia sp. HRI

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A1S6LRI1
• Locus tag: GF111_RS04205
• Protein ID: WP_071605322.1
• Coordinates: 858884..859138 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: GF111_RS04200
• Protein ID: WP_223294898.1
• Coordinates: 858543..858887 (-)
• Length: 115 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GF111_RS04180 (GF111_04180)	854884..855099	-	216	WP_071845399.1	ogr/Delta-like zinc finger family protein	-
GF111_RS04185 (GF111_04185)	855083..856158	+	1076	Protein_825	terminase family protein	-
GF111_RS04190 (GF111_04190)	856158..857180	+	1023	WP_047728002.1	phage portal protein	-
GF111_RS04195 (GF111_04195)	857218..858423	-	1206	WP_071845277.1	ISL3 family transposase	-
GF111_RS04200 (GF111_04200)	858543..858887	-	345	WP_223294898.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GF111_RS04205 (GF111_04205)	858884..859138	-	255	WP_071605322.1	type II toxin-antitoxin system HicA family toxin	Toxin
GF111_RS04210 (GF111_04210)	859792..860493	-	702	WP_038881175.1	hypothetical protein	-
GF111_RS04215 (GF111_04215)	860650..860910	+	261	WP_139145145.1	hypothetical protein	-
GF111_RS04220 (GF111_04220)	860943..861167	-	225	WP_047728004.1	hypothetical protein	-
GF111_RS04225 (GF111_04225)	861206..862181	-	976	Protein_833	replication endonuclease	-
GF111_RS04230 (GF111_04230)	862348..863091	-	744	WP_224217814.1	ankyrin repeat domain-containing protein	-
GF111_RS04235 (GF111_04235)	863181..863954	-	774	WP_038881165.1	ankyrin repeat domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	855056..866829	11773

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (23-81)

Antitoxin

• Uncharacterised protein family HicB (56-101)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 9495.97 Da
• Isoelectric Point: 11.1073

>T217076 WP_071605322.1 NZ_CP083690:c859138-858884 [Serratia sp. HRI]
MNKRHQKTLSDVFARPVNGSIKWSDIEALFTALGAEIHEREGSRIAVLLKGEKRVFHRPHPRPTTDKGAVNSIRIWLDSL
GIKP

Nucleotide

• Length: 255 bp

>T217076 NZ_CP113790:56823-57305 [Klebsiella variicola subsp. tropica]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGCAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Protein

• Length: 115 a.a.
• Molecular weight: 12531.10 Da
• Isoelectric Point: 4.5789

>AT217076 WP_223294898.1 NZ_CP083690:c858887-858543 [Serratia sp. HRI]
MMNNTLKIDGHTAVINFDPEIEMFRGEFVGLNGGADFYAYSVDELKKEGAISLAVFLDECHKDGIEPYKSYSGKVTTRLS
PERHQALAIAAQATGQSINELLNEGVDLVIEKHS

Nucleotide

• Length: 345 bp

>AT217076 NZ_CP113790:56569-56835 [Klebsiella variicola subsp. tropica]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Structures

Toxin

• AlphaFold DB: A0A1S6LRI1