Detailed information of TA system TA021707

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vagCD/VapC-VagC
• Location: 1711684..1712369
• Replicon: chromosome
• Accession: NC_008390
• Organism: Burkholderia ambifaria AMMD

Toxin (Protein)

• Gene name: vagD
• Uniprot ID: Q0BFH0
• Locus tag: BAMB_RS07815
• Protein ID: WP_011656832.1
• Coordinates: 1711947..1712369 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: Q0BFH1
• Locus tag: BAMB_RS07810
• Protein ID: WP_011656831.1
• Coordinates: 1711684..1711950 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BAMB_RS07795	1707212..1709464	+	2253	WP_011656829.1	TonB-dependent siderophore receptor	-
BAMB_RS07800	1709551..1710390	+	840	WP_006755049.1	folate-dependent phosphoribosylglycinamide formyltransferase PurN-like protein	-
BAMB_RS07805	1710390..1711406	+	1017	WP_011656830.1	acetyltransferase	-
BAMB_RS07810	1711684..1711950	+	267	WP_011656831.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
BAMB_RS07815	1711947..1712369	+	423	WP_011656832.1	type II toxin-antitoxin system VapC family toxin	Toxin
BAMB_RS07820	1712450..1712890	-	441	WP_011656833.1	MaoC family dehydratase	-
BAMB_RS07825	1712983..1714035	+	1053	WP_011656834.1	transposase	-
BAMB_RS07830	1714323..1715228	-	906	WP_011656835.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
BAMB_RS07835	1715197..1716267	-	1071	WP_011656836.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-130)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 14774.86 Da
• Isoelectric Point: 7.8895

>T21707 WP_011656832.1 NC_008390:1711947-1712369 [Burkholderia ambifaria AMMD]
VTTLYMLDTNICSFIMRERPSAVLSRLQSCVNAQHRIVVSAITYAEMRFGAVGRKASPKHAELVTAFVSRLDGVLSWDTA
AVDATTAIRVDLAARGTPIGANDASIAGHAIAAGAVLVTNNSREFSRVAGLSLEDWAASA

Nucleotide

• Length: 423 bp

>T21707 NC_008390:1711947-1712369 [Burkholderia ambifaria AMMD]
GTGACGACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCATCCGCGGTGTTGTCCCGGTT
GCAGTCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCGATCACCTATGCCGAGATGCGATTCGGCGCAGTCGGCA
GAAAGGCTTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTTTCGCGGCTGGATGGCGTGCTGTCGTGGGATACCGCG
GCGGTCGATGCAACGACCGCGATTCGCGTCGACCTTGCCGCACGTGGCACGCCGATCGGCGCGAACGACGCGTCGATCGC
CGGTCACGCGATCGCGGCCGGTGCCGTGCTTGTAACGAACAACAGTCGCGAATTCAGCCGTGTCGCGGGGTTGTCGCTCG
AAGATTGGGCAGCCTCGGCCTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10017.29 Da
• Isoelectric Point: 4.5498

>AT21707 WP_011656831.1 NC_008390:1711684-1711950 [Burkholderia ambifaria AMMD]
MRTVSIFKNARNQAIRIPKDMEFEGVTELEIRREGDTLLLRPVRPTWLSFATEPRADADFLVERPTVVEAGRFELPGADD
DAQTESAR

Nucleotide

• Length: 267 bp

>AT21707 NC_008390:1711684-1711950 [Burkholderia ambifaria AMMD]
ATGCGCACTGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGTGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACGTTGCTGCTGCGTCCGGTGCGGCCGACGTGGCTGTCGTTCGCGACTGAAC
CACGGGCCGATGCCGACTTCCTCGTCGAGCGCCCGACGGTCGTCGAAGCCGGTCGTTTCGAGCTGCCCGGCGCCGATGAC
GATGCACAGACGGAGTCGGCCCGGTGA

Structures

Toxin

• AlphaFold DB: Q0BFH0

Antitoxin

• AlphaFold DB: Q0BFH1