Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2123781..2124295 Replicon chromosome
Accession NZ_CP083671
Organism Staphylococcus aureus strain HL25870

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag K3A99_RS10500 Protein ID WP_000581792.1
Coordinates 2123781..2123990 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag K3A99_RS10505 Protein ID WP_000138932.1
Coordinates 2124002..2124295 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3A99_RS10480 (2119292) 2119292..2120647 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
K3A99_RS10485 (2120662) 2120662..2121732 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
K3A99_RS10490 (2122050) 2122050..2123252 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
K3A99_RS10495 (2123516) 2123516..2123653 - 138 WP_000828354.1 Lmo0850 family protein -
K3A99_RS10500 (2123781) 2123781..2123990 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
K3A99_RS10505 (2124002) 2124002..2124295 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
K3A99_RS10510 (2124461) 2124461..2125945 + 1485 WP_000571550.1 cardiolipin synthase -
K3A99_RS10515 (2125973) 2125973..2126620 + 648 WP_001187614.1 HD domain-containing protein -
K3A99_RS10520 (2127177) 2127177..2127239 + 63 Protein_2032 hypothetical protein -
K3A99_RS10525 (2127217) 2127217..2128532 - 1316 Protein_2033 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T217063 WP_000581792.1 NZ_CP083671:c2123990-2123781 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T217063 NZ_CP113789:c1191692-1191282 [Klebsiella variicola subsp. tropica]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTCCACGGTGTTGTGGCGGC
GCTGGTGCTGCTGGTCCCCTGGCCGCTGAGCTACACCCCGATCTGGCTGCTGCTGTTGTCGCTGGTGGTGTTTGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGAGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACCCCGTGGGTCATCAATAGCGGTATGCTGCTGCGGTTACGCCATGTCGATACCCGGCGCGG
GCAGCATTTGTGGCTGGCGGCGGATAGCATGGATGCCGGAGAATGGCGAGATTTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT217063 WP_000138932.1 NZ_CP083671:c2124295-2124002 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT217063 NZ_CP113789:c1191939-1191673 [Klebsiella variicola subsp. tropica]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACGCTCAGCGATACTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References