Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 1908204..1908980 Replicon chromosome
Accession NZ_CP083671
Organism Staphylococcus aureus strain HL25870

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag K3A99_RS09205 Protein ID WP_000031108.1
Coordinates 1908204..1908356 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag K3A99_RS09210 Protein ID WP_001251224.1
Coordinates 1908381..1908980 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3A99_RS09190 (1904409) 1904409..1905230 + 822 WP_000669380.1 RluA family pseudouridine synthase -
K3A99_RS09195 (1905685) 1905685..1907070 - 1386 WP_000116238.1 class II fumarate hydratase -
K3A99_RS09200 (1907266) 1907266..1907661 - 396 WP_000901018.1 hypothetical protein -
K3A99_RS09205 (1908204) 1908204..1908356 - 153 WP_000031108.1 SAS053 family protein Toxin
K3A99_RS09210 (1908381) 1908381..1908980 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
K3A99_RS09215 (1909139) 1909139..1909609 - 471 WP_224211716.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
K3A99_RS09220 (1909614) 1909614..1910741 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
K3A99_RS09225 (1910892) 1910892..1911614 - 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
K3A99_RS09230 (1911607) 1911607..1913064 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T217057 WP_000031108.1 NZ_CP083671:c1908356-1908204 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

>T217057 NZ_CP113784:1766960-1767244 [Citrobacter freundii]
ATGACTTATGAACTGGAATTCGACCCGAGAGCCTTAAAAGAGTGGCATAAACTGGGTGATACGGTGAAGGCTCAGTTTAA
GAAGAAGTTGGCCGACGTGTTGTTGAACCCCAGAATTGACTCTGCCCGTTTAAACGGTCTTCCAGATTGCTATAAAATTA
AGCTTAAATCGTCCGGCTATCGTCTGGTGTACCAGGTTCGGGATGAGGTTGTGATCGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCGGCCGTTTATCTCGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT217057 WP_001251224.1 NZ_CP083671:c1908980-1908381 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp

>AT217057 NZ_CP113784:1766728-1766970 [Citrobacter freundii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCTGTGCGATTACTGTTTCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACCGTTAGCGACA
GCGAAGATACACTGATTCAGACAGTCCGGGAGAGGCTGGCCAGCCCGCAAAAAGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References