Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 842725..843201 Replicon chromosome
Accession NZ_CP083671
Organism Staphylococcus aureus strain HL25870

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag K3A99_RS03965 Protein ID WP_000052076.1
Coordinates 842725..842913 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag K3A99_RS03970 Protein ID WP_001059690.1
Coordinates 842941..843201 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3A99_RS03935 (838753) 838753..839235 + 483 WP_000824489.1 hypothetical protein -
K3A99_RS03940 (839576) 839576..840262 + 687 WP_001574556.1 thermonuclease family protein -
K3A99_RS03945 (840619) 840619..840819 + 201 WP_001059082.1 cold-shock protein -
K3A99_RS03950 (841316) 841316..841534 - 219 WP_000005881.1 hypothetical protein -
K3A99_RS03955 (841595) 841595..841879 - 285 WP_001004403.1 hypothetical protein -
K3A99_RS03960 (841967) 841967..842536 - 570 WP_001106655.1 lipoprotein N-acylation protein LnsA -
K3A99_RS03965 (842725) 842725..842913 - 189 WP_000052076.1 hypothetical protein Toxin
K3A99_RS03970 (842941) 842941..843201 - 261 WP_001059690.1 hypothetical protein Antitoxin
K3A99_RS03975 (843543) 843543..843746 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
K3A99_RS03980 (843743) 843743..843979 - 237 WP_000368687.1 hypothetical protein -
K3A99_RS03985 (844204) 844204..844785 + 582 WP_001140696.1 histidine phosphatase family protein -
K3A99_RS03990 (844858) 844858..845475 - 618 WP_000255562.1 LysE/ArgO family amino acid transporter -
K3A99_RS03995 (845624) 845624..846118 - 495 WP_000569881.1 GNAT family N-acetyltransferase -
K3A99_RS04000 (846517) 846517..846939 - 423 WP_000974452.1 organic hydroperoxide resistance protein -
K3A99_RS04005 (847087) 847087..847803 + 717 WP_000150026.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-90)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T217056 WP_000052076.1 NZ_CP083671:c842913-842725 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T217056 NZ_CP113784:1510869-1511228 [Citrobacter freundii]
ATGACGAAACCACTATACTGGGTTGGACACGCCAGGAAAGATCTGCAGGGGATGCCGGAACATGTTCGGGATACGTTTGG
GTTTGCTCTTTGGCTTGCGCAGCAGGGTAAACAGCATTCGCAGACTAAATCATTAAAAGGATTTGGTGGCGCGGGGGTTC
TGGAAGTCGTTGAGGATCATCACGGCAACGCCTGGCGAGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAGTCCGTTTCCGGGAAGGCAACCCCGAAACCTGAAATTGACCTGATTTATCAGCGGCTCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCACATGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT217056 WP_001059690.1 NZ_CP083671:c843201-842941 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT217056 NZ_CP113784:1511218-1511535 [Citrobacter freundii]
ATGTCACATGAAGTGGAAGCTAGTAGCGGTAATGTTTACGCCGATTTAGGCGCGTATGACGCAGAACAGATGCAGTTGAA
AGCGCAACTGGCAATGGTGATTGGTGAGATTTTGCAACGCAAAGGGTTAACGCAGCAGCAGGCTGCGCAGCTACTGGGAA
TGACGCAGCCTAAACTTTCCAACCTGCTACGTGGTCAGTTTCGTGGTATCAGTGAAGCAAAGATGCTCGAATGCCTGGTG
AGACTGGGCCGTGATGTAGAGATTGTTGTCGGGGAAGAGGGCAATATGTCAGGAAAGCTGAAAGTGAAATTTGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References