Detailed information of TA system TA217054

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/-
• Location: 1710587..1711223
• Replicon: chromosome
• Accession: NZ_CP083658
• Organism: Acinetobacter variabilis strain FDAARGOS_1487

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: N9NZ70
• Locus tag: LA331_RS08435
• Protein ID: WP_005233755.1
• Coordinates: 1710587..1710973 (-)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: N9P9E0
• Locus tag: LA331_RS08440
• Protein ID: WP_005233752.1
• Coordinates: 1710966..1711223 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA331_RS08420 (LA331_08420)	1705895..1708177	-	2283	WP_005233758.1	TRAP transporter large permease subunit	-
LA331_RS08425 (LA331_08425)	1708355..1708927	-	573	WP_005233757.1	rhombosortase	-
LA331_RS08430 (LA331_08430)	1709000..1710040	-	1041	WP_005233756.1	hypothetical protein	-
LA331_RS08435 (LA331_08435)	1710587..1710973	-	387	WP_005233755.1	hypothetical protein	Toxin
LA331_RS08440 (LA331_08440)	1710966..1711223	-	258	WP_005233752.1	succinate dehydrogenase assembly factor 2	Antitoxin
LA331_RS08445 (LA331_08445)	1711406..1712578	+	1173	WP_005233750.1	acyl-CoA dehydrogenase family protein	-
LA331_RS08450 (LA331_08450)	1712631..1714121	-	1491	WP_005233748.1	NAD(P)/FAD-dependent oxidoreductase	-
LA331_RS08455 (LA331_08455)	1714329..1714694	-	366	WP_004786886.1	50S ribosomal protein L17	-
LA331_RS08460 (LA331_08460)	1714713..1715720	-	1008	WP_004786889.1	DNA-directed RNA polymerase subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Flavinator of succinate dehydrogenase (10-80)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 15194.30 Da
• Isoelectric Point: 10.0347

>T217054 WP_005233755.1 NZ_CP083658:c1710973-1710587 [Acinetobacter variabilis]
MDNRCFKLKRSKCALVFQLFIFAVLMFLLYQLLPVTIWLVCGVIGLVIYQLFYRKTPHIEQFEYLDGREWSLTAAAQGTR
RVLISHVIDHQAYIVVYFQHAKARPLLIWCDQLPFKQWKSLKVLTKML

Nucleotide

• Length: 387 bp

>T217054 NZ_CP113784:c918252-917977 [Citrobacter freundii]
ATGAAGGAAAAAGTGTTGTCTTTACGCAAAAAGCAAAAGAACACGCTGGATCAGCTTTTTAAAGCACCGACGCCGCAGGG
AATCAAGTGGTCGGAAATTGAGTCACTGATCAAGGCGTTAGGTGGCGAAATCAAAGAAGGACGAGGCTCGCGATGTAAAT
TTCTTTTAAATAAGAGCATTGCGAGTTTTCATAGACCACATCCTTCTCCGGATACAGATAAAGGCGCGGTCGAAAACGTA
CGTGACTGGTTAACAAGTATAGGGGTAAAACCATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 10308.82 Da
• Isoelectric Point: 4.5626

>AT217054 WP_005233752.1 NZ_CP083658:c1711223-1710966 [Acinetobacter variabilis]
MTDDITLEERKVIYRARRGLKEIDVYFDPYVKNYYLNADPFEKQMFAELVAQEDPDLLDWFMEVSEPPRPELKDFIKKLK
FYVHG

Nucleotide

• Length: 258 bp

>AT217054 NZ_CP113784:c917980-917621 [Citrobacter freundii]
ATGATCAAACCCAAAACGCCAAACTCAATGGAAATCGCCGGTCAACCTGCGGTAATTAATTATGTCCCTGAGCTTAATGC
GTTTCGCGGTAAGTTCCTGGGATTGTCAGGCTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAGGGGG
AGATCTCCTTACGAGAGTATCTTGATGATTGCTCTGCCGCAGGGATAGAACCTTACGCAAACCCGGAAAAGCTGAAGACG
TTTACTCTGCGCTATCCAGAGTCTTTCGGAGAACGTTTAAGTTTTGCGGCAGCGGAAGAACAGGTATCAGTCAATACATG
GATCATCGAAACGCTCAGCAAAAGTCTCAAACAGGCATAG

Structures

Toxin

• AlphaFold DB: N9NZ70

Antitoxin

• AlphaFold DB: N9P9E0