Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1136941..1137518 | Replicon | chromosome |
| Accession | NZ_CP083658 | ||
| Organism | Acinetobacter variabilis strain FDAARGOS_1487 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LA331_RS05495 | Protein ID | WP_034581200.1 |
| Coordinates | 1137330..1137518 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | N9MGE3 |
| Locus tag | LA331_RS05490 | Protein ID | WP_005236593.1 |
| Coordinates | 1136941..1137327 (-) | Length | 129 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LA331_RS05460 (LA331_05460) | 1132135..1133619 | - | 1485 | WP_005236586.1 | DUF935 family protein | - |
| LA331_RS05465 (LA331_05465) | 1133629..1135164 | - | 1536 | WP_005236587.1 | phage terminase large subunit | - |
| LA331_RS05470 (LA331_05470) | 1135165..1135629 | - | 465 | WP_005236588.1 | DUF2280 domain-containing protein | - |
| LA331_RS05475 (LA331_05475) | 1135677..1136318 | - | 642 | WP_005236589.1 | putative metallopeptidase | - |
| LA331_RS05480 (LA331_05480) | 1136278..1136718 | - | 441 | WP_005236591.1 | hypothetical protein | - |
| LA331_RS05485 (LA331_05485) | 1136708..1136884 | - | 177 | WP_164071344.1 | hypothetical protein | - |
| LA331_RS05490 (LA331_05490) | 1136941..1137327 | - | 387 | WP_005236593.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LA331_RS05495 (LA331_05495) | 1137330..1137518 | - | 189 | WP_034581200.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LA331_RS05500 (LA331_05500) | 1137811..1138206 | - | 396 | WP_005236595.1 | hypothetical protein | - |
| LA331_RS05510 (LA331_05510) | 1139026..1139466 | - | 441 | WP_005236596.1 | hypothetical protein | - |
| LA331_RS05515 (LA331_05515) | 1139479..1139991 | - | 513 | WP_005236597.1 | RusA family crossover junction endodeoxyribonuclease | - |
| LA331_RS05520 (LA331_05520) | 1139984..1140370 | - | 387 | WP_005236598.1 | hypothetical protein | - |
| LA331_RS05525 (LA331_05525) | 1140367..1140807 | - | 441 | WP_005236599.1 | hypothetical protein | - |
| LA331_RS05530 (LA331_05530) | 1140804..1141055 | - | 252 | WP_005236600.1 | hypothetical protein | - |
| LA331_RS05535 (LA331_05535) | 1141052..1141369 | - | 318 | WP_005236601.1 | hypothetical protein | - |
| LA331_RS05540 (LA331_05540) | 1141366..1141536 | - | 171 | WP_005236603.1 | hypothetical protein | - |
| LA331_RS05545 (LA331_05545) | 1141533..1141937 | - | 405 | WP_005236605.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1099757..1159948 | 60191 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7340.42 Da Isoelectric Point: 10.2954
>T217053 WP_034581200.1 NZ_CP083658:c1137518-1137330 [Acinetobacter variabilis]
MNSKDIIKRLEQEGWYKVGGKGDHEKYKHPEKSGHVVVPHPRKDMPIGTLRNIYKQAGWEWR
MNSKDIIKRLEQEGWYKVGGKGDHEKYKHPEKSGHVVVPHPRKDMPIGTLRNIYKQAGWEWR
Download Length: 189 bp
>T217053 NZ_CP113784:c895260-894892 [Citrobacter freundii]
ATGACGCTACAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTGACGCCTGGTGTCGCAGG
TATGCCTGACCCCGGTCGTGCGGAAGCGCTGATGTATCGGGTATTGAATCAAATCGAATATGAAGGTGTGACTGACGTGT
GGCTACTGGCGGCAATGCATTTGTTAGCCATTTCCCGTGGGCATATCTTTAATGATGGTAACAAGCGTACTGCGTTATTT
ATTACGTTGCTGTTTTTAAAACGTAATGGGATCGTATTATCTGCAAACCCTGATTTTGTCGCCATGACGGTTGAAGCGGC
AGCAGGACAACTCACGTTAGAACAAATTGCGCATCGTCTGCGCCATTAA
ATGACGCTACAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTGACGCCTGGTGTCGCAGG
TATGCCTGACCCCGGTCGTGCGGAAGCGCTGATGTATCGGGTATTGAATCAAATCGAATATGAAGGTGTGACTGACGTGT
GGCTACTGGCGGCAATGCATTTGTTAGCCATTTCCCGTGGGCATATCTTTAATGATGGTAACAAGCGTACTGCGTTATTT
ATTACGTTGCTGTTTTTAAAACGTAATGGGATCGTATTATCTGCAAACCCTGATTTTGTCGCCATGACGGTTGAAGCGGC
AGCAGGACAACTCACGTTAGAACAAATTGCGCATCGTCTGCGCCATTAA
Antitoxin
Download Length: 129 a.a. Molecular weight: 14492.40 Da Isoelectric Point: 4.4403
>AT217053 WP_005236593.1 NZ_CP083658:c1137327-1136941 [Acinetobacter variabilis]
MLYPVYVHKDEDTAYGLTFPDFEGCFSAADEMQDIQRMAQEAVEVHFDGEDIPLPTPSSPEQWLSDERFEGGFWLLVDID
TAKVNTKSVRINISMPEALVKRIDAMAKKQHLSRSAFLAKSAEMALHQ
MLYPVYVHKDEDTAYGLTFPDFEGCFSAADEMQDIQRMAQEAVEVHFDGEDIPLPTPSSPEQWLSDERFEGGFWLLVDID
TAKVNTKSVRINISMPEALVKRIDAMAKKQHLSRSAFLAKSAEMALHQ
Download Length: 387 bp
>AT217053 NZ_CP113784:c895478-895257 [Citrobacter freundii]
ATGCGCACTATGAACTATAGTGAAGCTCGACAAAACCTGGCTGAAGTGCTGGAGAGCGCTGTCACTGGTGTGCCTGTTAC
CATTACGCGCCGTGGTCATAAACCTGCGGTAATCATCAGCGCGGAAGAGTTTGAACGCTATCAGGCCGCCAGACTTGATG
ATGAATTTGCCGACATAATGATGATTCATGGTAATGAAATCAGGGAGCTGGCGGATAAATGA
ATGCGCACTATGAACTATAGTGAAGCTCGACAAAACCTGGCTGAAGTGCTGGAGAGCGCTGTCACTGGTGTGCCTGTTAC
CATTACGCGCCGTGGTCATAAACCTGCGGTAATCATCAGCGCGGAAGAGTTTGAACGCTATCAGGCCGCCAGACTTGATG
ATGAATTTGCCGACATAATGATGATTCATGGTAATGAAATCAGGGAGCTGGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|