Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazE-MazF
Location 973402..973964 Replicon chromosome
Accession NZ_CP083656
Organism Burkholderia vietnamiensis strain FDAARGOS_1488

Toxin (Protein)


Gene name mazF Uniprot ID A0A1B4LIX1
Locus tag LA325_RS29615 Protein ID WP_045579168.1
Coordinates 973402..973650 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A1B4LIN8
Locus tag LA325_RS29620 Protein ID WP_011879712.1
Coordinates 973644..973964 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA325_RS29585 (LA325_29585) 969155..969598 + 444 WP_043292565.1 hypothetical protein -
LA325_RS29590 (LA325_29590) 969599..969736 + 138 Protein_863 helix-turn-helix domain-containing protein -
LA325_RS29595 (LA325_29595) 969965..970297 + 333 WP_230459693.1 ArsA-related P-loop ATPase -
LA325_RS29600 (LA325_29600) 970318..970710 + 393 WP_011879707.1 DUF2703 domain-containing protein -
LA325_RS29605 (LA325_29605) 970748..971857 + 1110 WP_011879708.1 ArsO family NAD(P)H-dependent flavin-containing monooxygenase -
LA325_RS29615 (LA325_29615) 973402..973650 + 249 WP_045579168.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Toxin
LA325_RS29620 (LA325_29620) 973644..973964 + 321 WP_011879712.1 type II toxin-antitoxin system PemK/MazF family toxin Antitoxin
LA325_RS29625 (LA325_29625) 974492..974737 + 246 WP_131754457.1 hypothetical protein -
LA325_RS29630 (LA325_29630) 974709..975599 + 891 WP_144410678.1 hypothetical protein -
LA325_RS29635 (LA325_29635) 975641..975826 + 186 WP_043292729.1 hypothetical protein -
LA325_RS29640 (LA325_29640) 975911..976102 + 192 WP_124259719.1 hypothetical protein -
LA325_RS29645 (LA325_29645) 976095..976253 - 159 Protein_874 IS3 family transposase -
LA325_RS29650 (LA325_29650) 976273..976476 + 204 Protein_875 DUF1016 domain-containing protein -
LA325_RS29655 (LA325_29655) 976786..977646 + 861 WP_045579531.1 transporter substrate-binding domain-containing protein -
LA325_RS29660 (LA325_29660) 977739..978461 + 723 WP_011879718.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 938009..976491 38482


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

SpoVT-AbrB domain

(9-44)

Antitoxin

mRNA interferase PemK-like

(4-104)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 8979.19 Da        Isoelectric Point: 4.4929

>T217051 WP_045579168.1 NZ_CP083656:973402-973650 [Burkholderia vietnamiensis]
MKTTIRRMGNSQGVLIPKPVLAQLGLESEVEMEVENDAIVLRRPKHKAREGWAEASKALAESGDDALVMGEFSNADDAEL
AW

Download         Length: 249 bp

>T217051 NZ_CP113784:c333935-333528 [Citrobacter freundii]
GTGGTCCAGTGGCAATCTGATTTACGCGTATCATGGCGCGCGCAGTGGCTTTCACTGCTAATTCATGGGCTGGTCGCGGT
GTTTATTTTATTGATGCCCTGGCCATTGAGCTACACCCCATTATGGCTGGTTTTGCTCTCTCTGGTGGTATTCGATAGCG
TTCGCAGTCAGCGTCGAATCAACGCCTGTCAGGGTGAGATTCGGCTGTTGATGGATGGTCGTCTGCGCTGGCAAGGGCAA
GAGTGGTCTATCGTTAGCGCCCCCTGGATGGTTAAAACAGGCATGATGCTGCGTTTGCGCTCTGATGCCGGAAAACGTCA
ACATTTGTGGCTGGCGGCAGACAGTATGGATGATGCTGAGTGGCGGGATTTACGGCGGTTGATGCTGCAAAAGGCGAAGC
AGAAGTAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 11935.23 Da        Isoelectric Point: 10.5568

>AT217051 WP_011879712.1 NZ_CP083656:973644-973964 [Burkholderia vietnamiensis]
MVMRGEVWLVALDPTLGSEIQKTRPCVVVSPPEMHDHLRTVIVAPMTSKGRPVPFRIPVTFKRKHGLILLDQIRAVDKVR
LVKKEGAVADKTLLDTLRTLQEVFAE

Download         Length: 321 bp

>AT217051 NZ_CP113784:c334182-333916 [Citrobacter freundii]
ATGGATATTAACAACAAAGCACGTATTCATTGGGCATGCCGCCGCGGTATGCGCGAGCTGGATATCTCGATCATGCCGTT
TTTCGAACATGAATATGACAGCTTAAGTGACGAAGAAAAACGTATCTTTATCCGTCTGCTAGAATGTGATGATCCAGATT
TATTTAACTGGTTGATGAATCATGGGAAACCAGCTGATGCTGAGCTGGAGCAGATGGTGCGACTTATCCAGACACGGAAT
CGGGAACGTGGTCCAGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4LIX1

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4LIN8

References