Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) slvAT/RES(toxin)
Location 242657..243618 Replicon chromosome
Accession NZ_CP083656
Organism Burkholderia vietnamiensis strain FDAARGOS_1488

Toxin (Protein)


Gene name slvT Uniprot ID A0A1B4LHJ3
Locus tag LA325_RS26520 Protein ID WP_011880200.1
Coordinates 243085..243618 (+) Length 178 a.a.

Antitoxin (Protein)


Gene name slvA Uniprot ID A0A1B4LHE0
Locus tag LA325_RS26515 Protein ID WP_011880199.1
Coordinates 242657..243088 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA325_RS26490 (LA325_26485) 238313..238720 - 408 WP_011880193.1 DUF934 domain-containing protein -
LA325_RS26495 (LA325_26490) 238717..240507 - 1791 WP_011880194.1 nitrite/sulfite reductase -
LA325_RS26500 (LA325_26495) 240575..240787 - 213 WP_212170384.1 transposase -
LA325_RS26505 (LA325_26500) 241584..241811 + 228 WP_043292778.1 hypothetical protein -
LA325_RS26510 (LA325_26505) 241808..242242 + 435 WP_011880197.1 PIN domain-containing protein -
LA325_RS26515 (LA325_26510) 242657..243088 + 432 WP_011880199.1 hypothetical protein Antitoxin
LA325_RS26520 (LA325_26515) 243085..243618 + 534 WP_011880200.1 RES family NAD+ phosphorylase Toxin
LA325_RS26525 (LA325_26520) 244019..245002 + 984 WP_080938772.1 site-specific integrase -
LA325_RS26530 (LA325_26525) 244999..245382 + 384 WP_144410681.1 hypothetical protein -
LA325_RS26535 (LA325_26530) 245415..246232 + 818 WP_085954470.1 IS5-like element IS402 family transposase -
LA325_RS26540 (LA325_26535) 246282..246869 + 588 WP_080938773.1 tyrosine-type recombinase/integrase -
LA325_RS26545 (LA325_26540) 246866..247864 + 999 WP_045579687.1 tyrosine-type recombinase/integrase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 238313..323131 84818


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(11-168)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19147.77 Da        Isoelectric Point: 5.1857

>T217050 WP_011880200.1 NZ_CP083656:243085-243618 [Burkholderia vietnamiensis]
MILKPLQDIIAYRMHQPKWAVAPTSGAGAAKAGGRANRVGTPALYLALEVATAVAEYQQLSPLLPPGTLVSYRVTAAPVV
DFTAGFRGDHWSPLWESFFCDWRRDWFNKRIEPPSWVLGDEVIAAGAKGILFSSTQAAGGTNLVLFVDQLDNTDRLEVID
PAGALPRDQASWGESPA

Download         Length: 534 bp

>T217050 NZ_CP113783:4159440-4160753 [Pseudoxanthomonas sp. SE1]
ATGGGTGAGCTGCGGATATGGATGAACGGTGTGGAGGCCGCCACTTGGCAGGATGCGCAGCCCACGCGCCTGACTTACGT
TTCCAGTTGGCTGGCCTCATCTTTGGCGCGCCCTTTGTCCCTGTCGCTGCCCCTGCTGCCGGAGGGCACGTCGCACCGTG
GCGACGTGGTGGAGAACTACTTCGACAATTTGCTGCCAGACAGCACGAACATCCGTGCGCGCCTTCGCAATCGCTTCGCC
GTTCCTTCCAACAGCACGTTCGCGCTGCTGGAACAGATCGGCCGTGACTGCGTAGGCGCGATCCAGCTGTTGCCCGCGAA
CACTCTGCCGGACGAAGTACGCACCATCCAGGCCCGAGCCCTGGATGAGGCCGGTGTCGCCCGCCTTCTCCGGGGCGTGG
CATCCCCTCTGTTGCCCGGAAACCACGACGGAGATTCGTTCCGCCTGTCGTTGGCGGGCGCACAGGAAAAGACCGCGCTC
CTGTTTCACAACGGACAGTGGTGCGTCCCACTGGGGAGCACGCCCAGCACGCACATATTCAAACTGCCGCTCGGACGGGT
GGGAAACATGCGCGCCGACATGGCCTCGTCGGTAGAGAACGAGTGGCTTTGCATGCAACTGTTGCGTGCATTCGGCCTGC
CCGTGGCGAACACGTCCATCGGCAGATTCGAAGAGCTTCGCGTCCTGGTGGTCGAGCGTTTCGACAGGCGATTGTCCGGG
GACGGCAGCTGGTGGATCCGCCTGCCGCAGGAAGACCTTTGCCAGGTGTTCGGCCTGCCTTCTTCGCGCAAGTACGAAAA
CGATGGCGGGCCTGGGGTCGTGCAGATCATGGATCTGCTGCGTCAGTCCATCGAGCCCCGCGACCGCGAGATCTTCTTCA
AGACGCAGATCCTGTTCTGGCTGCTTGCCGCAACGGACGGACACGCGAAGAACTTCAGCCTGCACATCGAGCCACAGGGC
CGGTTCCGCCTGACGCCACTTTACGACGTGTTGTCCGTCTATCCCATTCTGGGCCATGGCCCTCAACAGCTGGATCCCCA
CGAGGCCGTGCTGGCCATGTCGGTGGTCGGCAAGAACAAGCACCGGAAACTGCTGAACGTACGCCGACGCCACTGGAACG
AAACAGCTCGGGCGTGCGGCGTTCGCCACGGCGCCGAACCCTGGCTGGAAGACCTCCTGGGAAGGATAGAGCCGGCGATC
ACGTCGGTCGCCGCTCAGCTGCCCACAGATTTTCCCGTCGAAGTGGCGCACGCCATCTTCGACGGCCTTCGACGCGCGGG
CGACAGATTGCGAGGAATGGCACCCGGCCATTGA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15299.19 Da        Isoelectric Point: 5.6277

>AT217050 WP_011880199.1 NZ_CP083656:242657-243088 [Burkholderia vietnamiensis]
MNTLATPSPAASAATPTGAAPVSFEAFLSSLREPDTAAPVLSARRYVAALNIDLQTLADQAHVHRNTVARAPESASVQHF
LREAIRVIRAATDLSGDVYRALFWYRNEPLAVFDYQTAETLVSAGRAEDVLRYIVSLEAGAAG

Download         Length: 432 bp

>AT217050 NZ_CP113783:4159176-4159436 [Pseudoxanthomonas sp. SE1]
ATGACGGCCGCGCAGTATCCGATCCAGACACCTCAGCAGCTGGCCCCTTTGTTGCGCGCCCTGCGCAAGAAGCAAGGCTT
GACCCAGGCCGACCTGGCCGAGCAGCTCGGTATCACACGACAAGCAGTAACCGCTCTGGAGGCCCGACCGGAAGCCGCGA
CATTCGAGCGCCTGATGAAAGTCTGGGCTGTCCTGGGCCTGCAAGTGTTGCTGGCTCCACGCACGCCCCCTTCGCCCTCG
CTGGATGCGGTGGAGTGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4LHJ3

Antitoxin

Source ID Structure
AlphaFold DB A0A1B4LHE0

References