Detailed information of TA system TA217049

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 241584..242242
• Replicon: chromosome
• Accession: NZ_CP083656
• Organism: Burkholderia vietnamiensis strain FDAARGOS_1488

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LA325_RS26510
• Protein ID: WP_011880197.1
• Coordinates: 241808..242242 (+)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A1B4LJE8
• Locus tag: LA325_RS26505
• Protein ID: WP_043292778.1
• Coordinates: 241584..241811 (+)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA325_RS26485 (LA325_26480)	237419..238099	-	681	WP_224383430.1	cupin domain-containing protein	-
LA325_RS26490 (LA325_26485)	238313..238720	-	408	WP_011880193.1	DUF934 domain-containing protein	-
LA325_RS26495 (LA325_26490)	238717..240507	-	1791	WP_011880194.1	nitrite/sulfite reductase	-
LA325_RS26500 (LA325_26495)	240575..240787	-	213	WP_212170384.1	transposase	-
LA325_RS26505 (LA325_26500)	241584..241811	+	228	WP_043292778.1	hypothetical protein	Antitoxin
LA325_RS26510 (LA325_26505)	241808..242242	+	435	WP_011880197.1	PIN domain-containing protein	Toxin
LA325_RS26515 (LA325_26510)	242657..243088	+	432	WP_011880199.1	hypothetical protein	-
LA325_RS26520 (LA325_26515)	243085..243618	+	534	WP_011880200.1	RES family NAD+ phosphorylase	-
LA325_RS26525 (LA325_26520)	244019..245002	+	984	WP_080938772.1	site-specific integrase	-
LA325_RS26530 (LA325_26525)	244999..245382	+	384	WP_144410681.1	hypothetical protein	-
LA325_RS26535 (LA325_26530)	245415..246232	+	818	WP_085954470.1	IS5-like element IS402 family transposase	-
LA325_RS26540 (LA325_26535)	246282..246869	+	588	WP_080938773.1	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	238313..323131	84818

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (3-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15721.10 Da
• Isoelectric Point: 7.2342

>T217049 WP_011880197.1 NZ_CP083656:241808-242242 [Burkholderia vietnamiensis]
VITYLLDVNVLIALLDPAHVQHEPAHAWFGRVGHSAWATCPLTENGVLRIIGNPKYPNTMVSPASVAPLVVQLRSHAGHT
FWSDDVSLLDEKHVDATRLLSSAQLTDTYLLALARAHKGKLATFDRRLVVDAVPNGGKHLELIP

Nucleotide

• Length: 435 bp

>T217049 NZ_CP113783:c3405268-3404948 [Pseudoxanthomonas sp. SE1]
ATGGTTGAAATAGTCTGGTCGGAGCCGGCGCTGGCCGACCTCGACGCCATCGCCGACTACATCGCCCTGGACAATCGTGC
GGCCGCCGTCGAGCTGGTCCGGCGCGTATTCGCGCATGTGGACCATCTGGCGGATCATCCCGACAGCGGCAGCCGACCTC
CGGAGCTGAAGCGCGGCCGCTACCGCCAGATCGTCGAACCGCCGTGCCGCGTGTTCTATCGATCAGAGCCGGGGCGCGTG
CTCCTCCTGCATGTCATGCGCAGTGAGCGACTGCTCCGGCCCGGCATGTTGCAAGCACGCAGGCCCATCAAACCACGCTG
A

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8080.14 Da
• Isoelectric Point: 8.9793

>AT217049 WP_043292778.1 NZ_CP083656:241584-241811 [Burkholderia vietnamiensis]
MRTTIDIDDDVLAFARERAKPGTSIGKVISDLARAALQRGTTNQSSRNGLPLMPVSATARPVTLDTVNQLRDDSL

Nucleotide

• Length: 228 bp

>AT217049 NZ_CP113783:c3405513-3405256 [Pseudoxanthomonas sp. SE1]
ATGCGCACCGAACTCGTCACCACGCTGAAGCGCCAGGCCACCGATCTGCTGGCCGATGTCGAACGGGATCGCGAGCCGAT
CCTGATCACGCAGCACGGATTGCCCAGCGCGTATCTTGTCGACGTGGAAACCTACGAGACGCTGTTGTCGCGCATGGCCG
TGCTGGAAGGCATCGCGCGCGGCGAACAGGCCGTCGCTGAAGGTCGGGCGGTCACCCATCGTCAAGCCAAGGACCGGCTT
GCCAGATGGTTGAAATAG

Structures

Antitoxin

• AlphaFold DB: A0A1B4LJE8