Detailed information of TA system TA217048

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapC-vagC/VapC-VagC
• Location: 2731286..2731923
• Replicon: chromosome
• Accession: NZ_CP083655
• Organism: Burkholderia vietnamiensis strain FDAARGOS_1488

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A1G5N4H6
• Locus tag: LA325_RS22525
• Protein ID: WP_034192973.1
• Coordinates: 2731522..2731923 (+)
• Length: 134 a.a.

Antitoxin (Protein)

• Gene name: vagC
• Uniprot ID: -
• Locus tag: LA325_RS22520
• Protein ID: WP_045578624.1
• Coordinates: 2731286..2731522 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA325_RS22505 (LA325_22500)	2727027..2728061	+	1035	WP_034192975.1	helix-turn-helix domain-containing protein	-
LA325_RS22510 (LA325_22505)	2728186..2729307	-	1122	WP_045578626.1	ADP-heptose--LPS heptosyltransferase	-
LA325_RS22515 (LA325_22510)	2729304..2731007	-	1704	WP_045578625.1	thiamine pyrophosphate-binding protein	-
LA325_RS22520 (LA325_22515)	2731286..2731522	+	237	WP_045578624.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
LA325_RS22525 (LA325_22520)	2731522..2731923	+	402	WP_034192973.1	type II toxin-antitoxin system VapC family toxin	Toxin
LA325_RS22530 (LA325_22525)	2731991..2733379	-	1389	WP_014722202.1	L-serine ammonia-lyase	-
LA325_RS22535 (LA325_22530)	2733410..2734546	-	1137	WP_045578623.1	alginate lyase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 134 a.a.
• Molecular weight: 14848.01 Da
• Isoelectric Point: 5.1682

>T217048 WP_034192973.1 NZ_CP083655:2731522-2731923 [Burkholderia vietnamiensis]
MPRYMLDTNMCIYLMKSQPEQVAKRFAQCYTGDVVMSAITCAELEYGVTACAAPARERRHLAALIEDIPVAPFDAAAAQA
YGPVRDATRAWKKDHLDKLIAAHAVSLDVVLVTNDERDFTSYPGLRLENWLND

Nucleotide

• Length: 402 bp

>T217048 NZ_CP113783:1776343-1776624 [Pseudoxanthomonas sp. SE1]
GTGATCCGGGACTTCGCCGACAAGGAAGCCGAGAAAGTCTGGAACGGCACGCCCTCGCGGCGTCTGCCGGCCGATATGCA
GGCCGTTGCCCGTCGCAAGCTTCGCATGCTGAACAACGCGGCCACGCTGGACGATCTGCGCATTCCGCCAGCGAACCGGT
TGGAGGTGTTGAAGGGCGACCGCAAGGGCCAGCACAGCATCCGGATCAACGATCAATGGCGCGTCTGCTTCCGCTGGAAG
GGTGGCGACGCGCACGGCGTGGACATCGTCGATTACCACTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9022.15 Da
• Isoelectric Point: 5.7316

>AT217048 WP_045578624.1 NZ_CP083655:2731286-2731522 [Burkholderia vietnamiensis]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERIGDEIRIRPARRPLTQVLEKFAKFAPDFMAEGRGDHEQAEREGL

Nucleotide

• Length: 237 bp

>AT217048 NZ_CP113783:1776648-1776938 [Pseudoxanthomonas sp. SE1]
ATGAAGACCCTGCCCAATATCCACCCCGGTGAAGTGCTGCTGGAGGAGTTCCTGTTGCCGATGGGCATCAGCCAGAATGC
GCTGGCGCGTGCCGCGGATGTGCCGCCGCGCCGTATCAACGAGATCGTGCTCGGAAAGCGCGGCGTCACGGCCGACACGG
CGGTCAGGCTGGCGGCAGCGCTGGGTACGAGCGAGCGTTTCTGGCTGGGTCTGCAGGCGGACTACGATCTGGAAGAGGCG
CACCGCTCGCTGGGCGCTGCGGTGTCCAGGATCGAGCGCATCGCGGCATGA

Structures

Toxin

• AlphaFold DB: A0A1G5N4H6