Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 44722..45361 Replicon chromosome
Accession NZ_CP083655
Organism Burkholderia vietnamiensis strain FDAARGOS_1488

Toxin (Protein)


Gene name vapC Uniprot ID A0A132DRA7
Locus tag LA325_RS10045 Protein ID WP_011883463.1
Coordinates 44942..45361 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132DHM6
Locus tag LA325_RS10040 Protein ID WP_011883461.1
Coordinates 44722..44955 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA325_RS10030 (LA325_10030) 41282..43654 + 2373 WP_045578500.1 xanthine dehydrogenase molybdopterin binding subunit -
LA325_RS10035 (LA325_10035) 43742..44395 + 654 WP_045578499.1 xanthine dehydrogenase accessory protein XdhC -
LA325_RS10040 (LA325_10040) 44722..44955 + 234 WP_011883461.1 DNA-binding protein Antitoxin
LA325_RS10045 (LA325_10045) 44942..45361 + 420 WP_011883463.1 type II toxin-antitoxin system VapC family toxin Toxin
LA325_RS10050 (LA325_10050) 45491..45892 + 402 WP_014722533.1 polyketide cyclase -
LA325_RS10055 (LA325_10055) 45933..46877 - 945 WP_011883467.1 LysR family transcriptional regulator -
LA325_RS10060 (LA325_10060) 46947..47585 - 639 WP_011883469.1 2-hydroxychromene-2-carboxylate isomerase -
LA325_RS10065 (LA325_10065) 47680..49113 - 1434 WP_045579402.1 TAXI family TRAP transporter solute-binding subunit -
LA325_RS10070 (LA325_10070) 49582..49938 + 357 WP_011883473.1 BON domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15649.85 Da        Isoelectric Point: 6.0999

>T217045 WP_011883463.1 NZ_CP083655:44942-45361 [Burkholderia vietnamiensis]
MFLVDTNVISEVRKRERADKGVMAFFRKAAQDDADLYLSVVTVGELRRGVEIIRHRGDKSQATRLENWLDGVLREFASNI
LAVDEEIGQLWGRLRVPHPEHSLDKLIAATALIHDLIVVTRNVDDFAGTGARVLNPFES

Download         Length: 420 bp

>T217045 NZ_CP113541:4649029-4649340 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8379.44 Da        Isoelectric Point: 5.0644

>AT217045 WP_011883461.1 NZ_CP083655:44722-44955 [Burkholderia vietnamiensis]
MATLLVRNVDEELVQSLRERAAANGRSAEAEHREILAKALRAPQRKTFAQVLMSIPNVGTDADFARVDDGEAANVFG

Download         Length: 234 bp

>AT217045 NZ_CP113541:4649337-4649783 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A132DRA7

Antitoxin

Source ID Structure
AlphaFold DB A0A132DHM6

References