Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 828748..829389 Replicon chromosome
Accession NZ_CP083654
Organism Burkholderia vietnamiensis strain FDAARGOS_1488

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LA325_RS03595 Protein ID WP_045578204.1
Coordinates 828748..829086 (+) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LA325_RS03600 Protein ID WP_011881499.1
Coordinates 829090..829389 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA325_RS03585 (LA325_03585) 825289..826722 - 1434 WP_045578203.1 aldehyde dehydrogenase family protein -
LA325_RS03590 (LA325_03590) 826751..828391 - 1641 WP_011881501.1 acetolactate synthase large subunit -
LA325_RS03595 (LA325_03595) 828748..829086 + 339 WP_045578204.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LA325_RS03600 (LA325_03600) 829090..829389 + 300 WP_011881499.1 putative addiction module antidote protein Antitoxin
LA325_RS03605 (LA325_03605) 829470..830756 - 1287 WP_045578205.1 DUF445 domain-containing protein -
LA325_RS03610 (LA325_03610) 830945..832165 - 1221 WP_045578206.1 anthranilate 1,2-dioxygenase system ferredoxin--NAD(+) reductase -
LA325_RS03615 (LA325_03615) 832155..832481 - 327 WP_045578207.1 anthranilate 1,2-dioxygenase ferredoxin subunit AndAb -
LA325_RS03620 (LA325_03620) 832508..832993 - 486 WP_034194948.1 anthranilate 1,2-dioxygenase small subunit AndAd -
LA325_RS03625 (LA325_03625) 833011..834282 - 1272 WP_014724582.1 anthranilate 1,2-dioxygenase large subunit AndAc -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(26-98)

Antitoxin

Uncharacterized protein HI1420

(6-93)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12652.46 Da        Isoelectric Point: 9.4958

>T217044 WP_045578204.1 NZ_CP083654:828748-829086 [Burkholderia vietnamiensis]
MVDISSNVPYSAPTYSIRTTEVFDTWFAGLQDRVARRRIQARIDRLPMGNPGDWKSAGSPVVEMRIDHGPGYRVYYVRRA
TIWVILLCGGDKSTQQADIRAAHAMLGRLDLE

Download         Length: 339 bp

>T217044 NZ_CP113541:c4647796-4647485 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10548.87 Da        Isoelectric Point: 6.0633

>AT217044 WP_011881499.1 NZ_CP083654:829090-829389 [Burkholderia vietnamiensis]
MDKISTRPWDSAAHLETDDDIADYFDACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKARA

Download         Length: 300 bp

>AT217044 NZ_CP113541:c4647484-4647194 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References