Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 92310..92953 Replicon plasmid unnamed2
Accession NZ_CP083653
Organism Citrobacter amalonaticus strain FDAARGOS_1489

Toxin (Protein)


Gene name vagD Uniprot ID -
Locus tag LA348_RS24170 Protein ID WP_121572286.1
Coordinates 92537..92953 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID -
Locus tag LA348_RS24165 Protein ID WP_121572285.1
Coordinates 92310..92540 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA348_RS24140 (LA348_24140) 87648..88427 - 780 WP_141227226.1 site-specific integrase -
LA348_RS24145 (LA348_24145) 88424..88990 - 567 WP_141227225.1 hypothetical protein -
LA348_RS24150 (LA348_24150) 89053..89415 - 363 WP_039265233.1 hypothetical protein -
LA348_RS24155 (LA348_24155) 90025..90963 + 939 WP_121572283.1 hypothetical protein -
LA348_RS24160 (LA348_24160) 91011..92036 - 1026 WP_121572284.1 hypothetical protein -
LA348_RS24165 (LA348_24165) 92310..92540 + 231 WP_121572285.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LA348_RS24170 (LA348_24170) 92537..92953 + 417 WP_121572286.1 type II toxin-antitoxin system VapC family toxin Toxin
LA348_RS24175 (LA348_24175) 93099..94169 - 1071 WP_141227224.1 hypothetical protein -
LA348_RS24180 (LA348_24180) 94960..95589 - 630 WP_063136851.1 DUF1349 domain-containing protein -
LA348_RS24185 (LA348_24185) 95671..96852 - 1182 WP_141227223.1 MFS transporter -
LA348_RS24190 (LA348_24190) 96886..97644 - 759 WP_047732337.1 DeoR/GlpR family DNA-binding transcription regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..125776 125776


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15133.65 Da        Isoelectric Point: 6.2225

>T217043 WP_121572286.1 NZ_CP083653:92537-92953 [Citrobacter amalonaticus]
VNKTYMLDTCICSFIMREQPEAVLKHLEQAVLRNQRIVIPVITYAEMRFGATGPKVSPRHIELVDAFCARLDAILPWDSA
AVDATTEIKVALRLAGTPIGPNDTAIAGHAIAAGVVLVTNNVREFERVPGLVLEDWVK

Download         Length: 417 bp

>T217043 NZ_CP113541:c4327329-4326838 [Salmonella enterica]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGGAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTCGCTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGTGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTATCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8779.86 Da        Isoelectric Point: 4.1211

>AT217043 WP_121572285.1 NZ_CP083653:92310-92540 [Citrobacter amalonaticus]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVPPTWDSFLELEKADPDFMAEREDVVTDEGRFDL

Download         Length: 231 bp

>AT217043 NZ_CP113541:c4327619-4327326 [Salmonella enterica]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGCGAAACCCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATCGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGCGCTGCCGCAGAGGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAGTTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References