Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4024616..4025386 | Replicon | chromosome |
| Accession | NZ_CP083651 | ||
| Organism | Citrobacter amalonaticus strain FDAARGOS_1489 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A7L6YXS7 |
| Locus tag | LA348_RS19040 | Protein ID | WP_046401692.1 |
| Coordinates | 4024616..4024996 (-) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | LA348_RS19045 | Protein ID | WP_224267599.1 |
| Coordinates | 4025054..4025386 (-) | Length | 111 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LA348_RS19015 (LA348_19015) | 4020328..4021173 | + | 846 | WP_042323385.1 | fructoselysine 6-kinase | - |
| LA348_RS19020 (LA348_19020) | 4021235..4022554 | + | 1320 | WP_042323383.1 | anaerobic C4-dicarboxylate transporter | - |
| LA348_RS19025 (LA348_19025) | 4022968..4023819 | - | 852 | WP_090050165.1 | DUF4942 domain-containing protein | - |
| LA348_RS19030 (LA348_19030) | 4023902..4024098 | - | 197 | Protein_3706 | hypothetical protein | - |
| LA348_RS19035 (LA348_19035) | 4024128..4024619 | - | 492 | WP_046401693.1 | DUF5983 family protein | - |
| LA348_RS19040 (LA348_19040) | 4024616..4024996 | - | 381 | WP_046401692.1 | TA system toxin CbtA family protein | Toxin |
| LA348_RS19045 (LA348_19045) | 4025054..4025386 | - | 333 | WP_224267599.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LA348_RS19050 (LA348_19050) | 4025442..4025663 | - | 222 | WP_038633763.1 | DUF987 domain-containing protein | - |
| LA348_RS19055 (LA348_19055) | 4025675..4026160 | - | 486 | WP_038642868.1 | DNA repair protein RadC | - |
| LA348_RS19060 (LA348_19060) | 4026213..4026608 | - | 396 | WP_046401710.1 | antirestriction protein | - |
| LA348_RS19065 (LA348_19065) | 4026686..4026949 | - | 264 | WP_001149870.1 | hypothetical protein | - |
| LA348_RS19070 (LA348_19070) | 4026949..4027767 | - | 819 | WP_001234374.1 | DUF932 domain-containing protein | - |
| LA348_RS19075 (LA348_19075) | 4027883..4028133 | - | 251 | Protein_3715 | DUF905 domain-containing protein | - |
| LA348_RS19080 (LA348_19080) | 4028324..4028791 | - | 468 | WP_000727137.1 | hypothetical protein | - |
| LA348_RS19085 (LA348_19085) | 4028888..4029289 | - | 402 | WP_000819262.1 | hypothetical protein | - |
| LA348_RS19090 (LA348_19090) | 4029495..4030382 | - | 888 | WP_040229917.1 | 50S ribosome-binding GTPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4024616..4043600 | 18984 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 14234.49 Da Isoelectric Point: 10.6224
>T217038 WP_046401692.1 NZ_CP083651:c4024996-4024616 [Citrobacter amalonaticus]
MQTLSAIPTRKAPSRPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEKIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQKQHS
MQTLSAIPTRKAPSRPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEKIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQKQHS
Download Length: 381 bp
>T217038 NZ_CP113541:2385164-2385448 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA
Antitoxin
Download Length: 111 a.a. Molecular weight: 12343.02 Da Isoelectric Point: 6.6289
>AT217038 WP_224267599.1 NZ_CP083651:c4025386-4025054 [Citrobacter amalonaticus]
ISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQAFPALLKQLELMLVSGELNPRHQHCVTLYA
KGLTCEADSLGSHGYIYTAIYPTPDDSITR
ISEPWWGLKRNITPCFGARLVQEGNRLHYLADRASITGTFTDADLRHLDQAFPALLKQLELMLVSGELNPRHQHCVTLYA
KGLTCEADSLGSHGYIYTAIYPTPDDSITR
Download Length: 333 bp
>AT217038 NZ_CP113541:2384926-2385174 [Salmonella enterica]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGATCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGCAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|