Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 3749246..3749871 Replicon chromosome
Accession NZ_CP083651
Organism Citrobacter amalonaticus strain FDAARGOS_1489

Toxin (Protein)


Gene name vapC Uniprot ID A0A381GI10
Locus tag LA348_RS17730 Protein ID WP_042998865.1
Coordinates 3749246..3749632 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LA348_RS17735 Protein ID WP_192575752.1
Coordinates 3749632..3749871 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA348_RS17710 (LA348_17710) 3744599..3745936 + 1338 WP_086512772.1 VWA domain-containing protein -
LA348_RS17715 (LA348_17715) 3745954..3747450 + 1497 WP_061069451.1 HAMP domain-containing sensor histidine kinase -
LA348_RS17720 (LA348_17720) 3747455..3748141 + 687 WP_061069450.1 response regulator transcription factor -
LA348_RS17725 (LA348_17725) 3748286..3749215 + 930 WP_042998866.1 formate dehydrogenase accessory protein FdhE -
LA348_RS17730 (LA348_17730) 3749246..3749632 - 387 WP_042998865.1 type II toxin-antitoxin system VapC family toxin Toxin
LA348_RS17735 (LA348_17735) 3749632..3749871 - 240 WP_192575752.1 CopG family transcriptional regulator Antitoxin
LA348_RS17740 (LA348_17740) 3750081..3751007 + 927 WP_061069448.1 alpha/beta hydrolase -
LA348_RS17745 (LA348_17745) 3751023..3751964 - 942 WP_042998862.1 fatty acid biosynthesis protein FabY -
LA348_RS17750 (LA348_17750) 3752009..3752446 - 438 WP_044265155.1 D-aminoacyl-tRNA deacylase -
LA348_RS17755 (LA348_17755) 3752443..3753315 - 873 WP_044257165.1 virulence factor BrkB family protein -
LA348_RS17760 (LA348_17760) 3753309..3753908 - 600 WP_061069447.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-46)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14404.65 Da        Isoelectric Point: 9.4114

>T217037 WP_042998865.1 NZ_CP083651:c3749632-3749246 [Citrobacter amalonaticus]
MQKGPVLFDTNILIDLFSGRQEAQQVLEAYPPQNAISLVTWMEVMVGAKKYHQEYRTRVALSAFNIIGVSQEIAERSVNL
RQEYGMKLPDAIILATAQIHRFALVTRNTRDFAGIPGVITPYQLQAGR

Download         Length: 387 bp

>T217037 NZ_CP113541:2043869-2043972 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9226.41 Da        Isoelectric Point: 4.2075

>AT217037 WP_192575752.1 NZ_CP083651:c3749871-3749632 [Citrobacter amalonaticus]
MAGMDMGRILLDLSDEMIKRLDDLKQQRNLPRAELLREAVEQYLERQGQAETTISNALGLWQGCEEDGVEYQKTLREEW

Download         Length: 240 bp

>AT217037 NZ_CP113541:c2043974-2043829 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A381GI10

Antitoxin

Source ID Structure

References