217035

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 3221824..3222493 Replicon chromosome
Accession NZ_CP083651
Organism Citrobacter amalonaticus strain FDAARGOS_1489

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag LA348_RS15285 Protein ID WP_141227650.1
Coordinates 3221824..3222156 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag LA348_RS15290 Protein ID WP_097485886.1
Coordinates 3222176..3222493 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA348_RS15260 (LA348_15260) 3217514..3218536 + 1023 WP_000155278.1 autoinducer 2 ABC transporter substrate-binding protein LsrB -
LA348_RS15265 (LA348_15265) 3218565..3219440 + 876 WP_000774153.1 3-hydroxy-5-phosphonooxypentane-2,4-dione thiolase -
LA348_RS15270 (LA348_15270) 3219489..3219779 + 291 WP_044264508.1 (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase -
LA348_RS15275 (LA348_15275) 3219790..3220536 + 747 WP_061069582.1 epimerase -
LA348_RS15280 (LA348_15280) 3221072..3221557 - 486 WP_097485888.1 GNAT family N-acetyltransferase -
LA348_RS15285 (LA348_15285) 3221824..3222156 - 333 WP_141227650.1 TA system toxin CbtA family protein Toxin
LA348_RS15290 (LA348_15290) 3222176..3222493 - 318 WP_097485886.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LA348_RS15295 (LA348_15295) 3222512..3222733 - 222 WP_097485885.1 DUF987 domain-containing protein -
LA348_RS15300 (LA348_15300) 3222742..3223224 - 483 WP_141227651.1 DNA repair protein RadC -
LA348_RS15305 (LA348_15305) 3223233..3223691 - 459 WP_097485883.1 antirestriction protein -
LA348_RS15310 (LA348_15310) 3223777..3224013 - 237 WP_025760300.1 DUF905 domain-containing protein -
LA348_RS15315 (LA348_15315) 3224091..3224501 - 411 WP_039556163.1 hypothetical protein -
LA348_RS15320 (LA348_15320) 3224568..3225005 - 438 WP_141227652.1 hypothetical protein -
LA348_RS15325 (LA348_15325) 3225047..3225583 - 537 WP_032686431.1 DUF4339 domain-containing protein -
LA348_RS15330 (LA348_15330) 3225609..3226319 - 711 WP_025760296.1 DeoR family transcriptional regulator -
LA348_RS15335 (LA348_15335) 3226528..3227352 - 825 WP_097485882.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3221824..3242777 20953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-100)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 12476.48 Da        Isoelectric Point: 6.7016

>T217035 WP_141227650.1 NZ_CP083651:c3222156-3221824 [Citrobacter amalonaticus]
MKTLPATISRATKPCLSPVAVWQMLLTRLLDQHYGLTLNDTPFSDETVIKGHIDAGITLADAVNFLVEKYELVRIDRKGF
SCHEQSPYLRGIDILRAKRELDYCNEIVIT

Download         Length: 333 bp

>T217035 NZ_CP113541:879313-879711 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11939.48 Da        Isoelectric Point: 6.6998

>AT217035 WP_097485886.1 NZ_CP083651:c3222493-3222176 [Citrobacter amalonaticus]
MSNITWGLQRDTTPRLGARLVQEGNRLYYLADRASITGKFSDAECRKLDETFPHFISQMESMLTTGELNPRHAHRVTLYL
DGFTCEADTLGSCGYVYIAVYPTQR

Download         Length: 318 bp

>AT217035 NZ_CP113541:879086-879313 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References