Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3106286..3106940 Replicon chromosome
Accession NZ_CP083651
Organism Citrobacter amalonaticus strain FDAARGOS_1489

Toxin (Protein)


Gene name cptA Uniprot ID A0A3Q8D714
Locus tag LA348_RS14705 Protein ID WP_044254016.1
Coordinates 3106286..3106693 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0F6TWP9
Locus tag LA348_RS14710 Protein ID WP_042322123.1
Coordinates 3106674..3106940 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA348_RS14685 (LA348_14685) 3102191..3103924 - 1734 WP_042999369.1 single-stranded-DNA-specific exonuclease RecJ -
LA348_RS14690 (LA348_14690) 3103930..3104643 - 714 WP_042999368.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LA348_RS14695 (LA348_14695) 3104667..3105563 - 897 WP_042999367.1 site-specific tyrosine recombinase XerD -
LA348_RS14700 (LA348_14700) 3105664..3106185 + 522 WP_042999366.1 flavodoxin FldB -
LA348_RS14705 (LA348_14705) 3106286..3106693 - 408 WP_044254016.1 protein YgfX Toxin
LA348_RS14710 (LA348_14710) 3106674..3106940 - 267 WP_042322123.1 FAD assembly factor SdhE Antitoxin
LA348_RS14715 (LA348_14715) 3107197..3108177 + 981 WP_061069610.1 tRNA-modifying protein YgfZ -
LA348_RS14720 (LA348_14720) 3108258..3108917 - 660 WP_044264418.1 hemolysin III family protein -
LA348_RS14725 (LA348_14725) 3109080..3109391 - 312 WP_042999362.1 N(4)-acetylcytidine aminohydrolase -
LA348_RS14730 (LA348_14730) 3109444..3110172 + 729 WP_044264419.1 MurR/RpiR family transcriptional regulator -
LA348_RS14735 (LA348_14735) 3110292..3111725 + 1434 WP_141227643.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15863.86 Da        Isoelectric Point: 11.6030

>T217034 WP_044254016.1 NZ_CP083651:c3106693-3106286 [Citrobacter amalonaticus]
VVLWQSDLRVSWRAQWLSLLLHGLVAAAILLMPWPLSYTPLWLILLSLVVFDCVRSQRRINARQGEVKLLMDGRLRWQGQ
DWLIVSAPWMIKTGMMLRLRSETGKRQHLWLAADSMDKAEWRDLRRLMMQPSTQG

Download         Length: 408 bp

>T217034 NZ_CP113541:868446-868859 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10544.06 Da        Isoelectric Point: 5.1496

>AT217034 WP_042322123.1 NZ_CP083651:c3106940-3106674 [Citrobacter amalonaticus]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RDRGPVAI

Download         Length: 267 bp

>AT217034 NZ_CP113541:868199-868465 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Q8D714

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6TWP9

References