Detailed information of TA system TA021703

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-RelB
• Location: 2661480..2662078
• Replicon: chromosome
• Accession: NC_008380
• Organism: Rhizobium leguminosarum bv. viciae 3841

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8G2MT35
• Locus tag: RL_RS12995
• Protein ID: WP_027667450.1
• Coordinates: 2661480..2661773 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q1MGB2
• Locus tag: RL_RS13000
• Protein ID: WP_011652079.1
• Coordinates: 2661770..2662078 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RL_RS12975	2657929..2659062	+	1134	WP_028741306.1	esterase-like activity of phytase family protein	-
RL_RS12980	2659179..2660396	+	1218	WP_003539854.1	AI-2E family transporter	-
RL_RS12985	2660416..2660874	-	459	WP_011652077.1	GNAT family N-acetyltransferase	-
RL_RS12990	2661004..2661423	+	420	WP_011652078.1	hypothetical protein	-
RL_RS12995	2661480..2661773	-	294	WP_027667450.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
RL_RS13000	2661770..2662078	-	309	WP_011652079.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
RL_RS13005	2662214..2663356	-	1143	WP_011652080.1	DUF2336 domain-containing protein	-
RL_RS13010	2663465..2664076	-	612	WP_011652081.1	flavin reductase family protein	-
RL_RS13015	2664076..2664660	-	585	WP_011652082.1	nitroreductase	-
RL_RS13020	2664774..2665874	+	1101	WP_011652083.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-58)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11116.82 Da
• Isoelectric Point: 8.5341

>T21703 WP_027667450.1 NC_008380:c2661773-2661480 [Rhizobium leguminosarum bv. viciae 3841]
VRLVWARYALSDRENIFTYIEIENPRAAVHVDQKIVLAVRRLVEFPESGRPGRIAGTRELVIPSTPYIAAYVVHEDRIRI
LRVLHGAQIWPDAISTD

Nucleotide

• Length: 294 bp

>T21703 NC_008380:c2661773-2661480 [Rhizobium leguminosarum bv. viciae 3841]
GTGAGGCTTGTCTGGGCGAGGTACGCGTTGTCCGACCGAGAGAATATTTTCACATATATTGAGATCGAGAATCCAAGGGC
GGCAGTTCATGTTGACCAGAAAATCGTTCTTGCTGTTCGCCGCCTCGTCGAATTCCCGGAAAGCGGAAGGCCGGGAAGAA
TCGCGGGCACACGGGAGCTGGTAATCCCAAGCACGCCTTACATCGCCGCGTATGTGGTGCATGAAGACCGAATCCGTATT
CTTCGCGTCCTCCACGGCGCCCAGATTTGGCCTGACGCCATATCAACCGACTGA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11285.67 Da
• Isoelectric Point: 4.7051

>AT21703 WP_011652079.1 NC_008380:c2662078-2661770 [Rhizobium leguminosarum bv. viciae 3841]
MASNALVQTRIDAAVKDRATAVLENMGLTVSDVVRILLTRTANEGALPLELISNSDAYDAWFRGKVLEALHDTRPDVDDT
EVETGFEKRREAALRKSQVDRS

Nucleotide

• Length: 309 bp

>AT21703 NC_008380:c2662078-2661770 [Rhizobium leguminosarum bv. viciae 3841]
ATGGCGTCAAACGCACTCGTTCAAACTCGCATAGATGCTGCGGTCAAGGATCGCGCCACGGCTGTTCTGGAAAACATGGG
CCTGACCGTCTCGGATGTCGTCCGTATTCTGTTGACCCGCACAGCGAATGAGGGAGCTCTTCCGCTGGAGCTTATCAGCA
ACAGTGACGCTTACGATGCGTGGTTTCGCGGGAAAGTCCTGGAAGCTCTCCATGACACGCGACCGGATGTTGACGATACC
GAGGTCGAGACCGGTTTTGAGAAGAGGCGCGAGGCGGCACTTCGGAAGAGCCAGGTGGATCGATCGTGA

Structures

Antitoxin

• AlphaFold DB: Q1MGB2