Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 480311..480931 Replicon chromosome
Accession NZ_CP083651
Organism Citrobacter amalonaticus strain FDAARGOS_1489

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LA348_RS02140 Protein ID WP_001280991.1
Coordinates 480311..480529 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3Q8DH98
Locus tag LA348_RS02145 Protein ID WP_042324455.1
Coordinates 480557..480931 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA348_RS02110 (LA348_02110) 475964..476560 + 597 WP_061070461.1 membrane protein -
LA348_RS02115 (LA348_02115) 476643..476996 + 354 WP_043001561.1 DUF1428 family protein -
LA348_RS02120 (LA348_02120) 477036..478586 - 1551 WP_054176085.1 EAL domain-containing protein -
LA348_RS02125 (LA348_02125) 478809..478949 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LA348_RS02130 (LA348_02130) 478999..479469 - 471 WP_061070460.1 YlaC family protein -
LA348_RS02135 (LA348_02135) 479583..480134 - 552 WP_044258934.1 maltose O-acetyltransferase -
LA348_RS02140 (LA348_02140) 480311..480529 - 219 WP_001280991.1 HHA domain-containing protein Toxin
LA348_RS02145 (LA348_02145) 480557..480931 - 375 WP_042324455.1 Hha toxicity modulator TomB Antitoxin
LA348_RS02150 (LA348_02150) 481443..484592 - 3150 WP_043001557.1 efflux RND transporter permease AcrB -
LA348_RS02155 (LA348_02155) 484615..485808 - 1194 WP_043001556.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T217025 WP_001280991.1 NZ_CP083651:c480529-480311 [Citrobacter amalonaticus]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T217025 NZ_CP113540:c4021869-4021582 [Salmonella enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8989

>AT217025 WP_042324455.1 NZ_CP083651:c480931-480557 [Citrobacter amalonaticus]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT217025 NZ_CP113540:c4021595-4021293 [Salmonella enterica]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A3Q8DH98

References