Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-YefM
Location 1230034..1230539 Replicon chromosome
Accession NZ_CP083648
Organism Corynebacterium coyleae strain FDAARGOS_1492

Toxin (Protein)


Gene name relB Uniprot ID A0A1F1UTI2
Locus tag LA324_RS05700 Protein ID WP_070422282.1
Coordinates 1230285..1230539 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1F1UTG6
Locus tag LA324_RS05695 Protein ID WP_070422281.1
Coordinates 1230034..1230285 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA324_RS05675 (LA324_05675) 1225564..1227060 + 1497 WP_070483883.1 malate dehydrogenase (quinone) -
LA324_RS05680 (LA324_05680) 1227088..1228293 - 1206 WP_224213807.1 protein adenylyltransferase SelO family protein -
LA324_RS05685 (LA324_05685) 1228318..1229058 + 741 WP_224213808.1 uroporphyrinogen-III C-methyltransferase -
LA324_RS05690 (LA324_05690) 1229042..1229992 + 951 WP_224213809.1 methyltransferase -
LA324_RS05695 (LA324_05695) 1230034..1230285 + 252 WP_070422281.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LA324_RS05700 (LA324_05700) 1230285..1230539 + 255 WP_070422282.1 Txe/YoeB family addiction module toxin Toxin
LA324_RS05705 (LA324_05705) 1230536..1231264 - 729 WP_070422283.1 NAD-dependent deacylase -
LA324_RS05710 (LA324_05710) 1231374..1232594 + 1221 WP_101740393.1 sodium/glutamate symporter -
LA324_RS05715 (LA324_05715) 1232598..1233320 - 723 WP_070829048.1 DUF1648 domain-containing protein -
LA324_RS05720 (LA324_05720) 1233536..1234453 + 918 WP_224213810.1 hypothetical protein -
LA324_RS05725 (LA324_05725) 1234457..1235122 - 666 WP_224213811.1 peroxide stress protein YaaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-67)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10039.42 Da        Isoelectric Point: 9.6972

>T217021 WP_070422282.1 NZ_CP083648:1230285-1230539 [Corynebacterium coyleae]
MRLVWTTNAWEDYLYWQGNDKKTLRRVNQLLRDTLRDPFEGIGKPEPLKYGAEGAWSRRITQEHRLVYTVAGTDLVILQA
RYHY

Download         Length: 255 bp

>T217021 NZ_CP113540:c2478182-2478027 [Salmonella enterica]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9278.27 Da        Isoelectric Point: 4.3304

>AT217021 WP_070422281.1 NZ_CP083648:1230034-1230285 [Corynebacterium coyleae]
MSISASEARRTLYPLIERVNNDRDPVEIVSRHGNAVLMAADDYAAWVETAYLFKSPENARRLTQAYEEALNGAVAEHDID
LDA

Download         Length: 252 bp

>AT217021 NZ_CP113540:2478194-2478252 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F1UTI2

Antitoxin

Source ID Structure
AlphaFold DB A0A1F1UTG6

References