Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 561220..562009 Replicon chromosome
Accession NZ_CP083648
Organism Corynebacterium coyleae strain FDAARGOS_1492

Toxin (Protein)


Gene name tacT Uniprot ID A0A1F1UW51
Locus tag LA324_RS02495 Protein ID WP_070422117.1
Coordinates 561220..561732 (-) Length 171 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A1H4JNZ8
Locus tag LA324_RS02500 Protein ID WP_070422119.1
Coordinates 561725..562009 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA324_RS02475 (LA324_02475) 556623..557471 - 849 WP_224213464.1 PRC and DUF2382 domain-containing protein -
LA324_RS02480 (LA324_02480) 557773..558576 - 804 WP_224213465.1 hypothetical protein -
LA324_RS02485 (LA324_02485) 558629..559918 + 1290 WP_070451081.1 adenylosuccinate synthase -
LA324_RS02490 (LA324_02490) 560164..561249 + 1086 WP_141739371.1 hypothetical protein -
LA324_RS02495 (LA324_02495) 561220..561732 - 513 WP_070422117.1 GNAT family N-acetyltransferase Toxin
LA324_RS02500 (LA324_02500) 561725..562009 - 285 WP_070422119.1 DUF1778 domain-containing protein Antitoxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 546128..562009 15881


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(25-142)

Antitoxin

Vibrio phage ICP1, Orf50

(3-86)


Sequences

Toxin        


Download         Length: 171 a.a.        Molecular weight: 18977.63 Da        Isoelectric Point: 8.8932

>T217020 WP_070422117.1 NZ_CP083648:c561732-561220 [Corynebacterium coyleae]
MTRDIIQPPRTIEKEDDVAGFSCGVESLDKWLKENAWKNQRANNSVTYVTTLNDKVVGYYALASGGVSRDALPKRFRNNR
PKDVPIILLGRFAVDSRAQGRQLGKSLLQDMFRRAIAAAEIIGAAAILIHAHDESAKQFYLHNANFHEMPGEPLHLLLPV
ESLIQQAQNS

Download         Length: 513 bp

>T217020 NZ_CP113540:c989058-988531 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10623.01 Da        Isoelectric Point: 4.5849

>AT217020 WP_070422119.1 NZ_CP083648:c562009-561725 [Corynebacterium coyleae]
MTQPKVKRLHLRTTEVQDETLRSAAEAQDVPVSDFVLGSAMIEAEKILADRRWFELSDEDFAKFEKALDTPVDGTKLARL
LASDSVFGKEFHLD

Download         Length: 285 bp

>AT217020 NZ_CP113540:c989345-989055 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F1UW51

Antitoxin

Source ID Structure
AlphaFold DB A0A1H4JNZ8

References