Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4039339..4039855 Replicon chromosome
Accession NZ_CP083643
Organism Enterobacter bugandensis strain FDAARGOS_1496

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LA326_RS19200 Protein ID WP_088204684.1
Coordinates 4039339..4039623 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8E1RL94
Locus tag LA326_RS19205 Protein ID WP_023331889.1
Coordinates 4039613..4039855 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA326_RS19185 (LA326_19185) 4035705..4036277 + 573 WP_088204682.1 fructose PTS transporter subunit IIA -
LA326_RS19190 (LA326_19190) 4036647..4038785 + 2139 WP_048960133.1 anaerobic ribonucleoside-triphosphate reductase -
LA326_RS19195 (LA326_19195) 4038871..4039335 + 465 WP_088204683.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LA326_RS19200 (LA326_19200) 4039339..4039623 - 285 WP_088204684.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LA326_RS19205 (LA326_19205) 4039613..4039855 - 243 WP_023331889.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LA326_RS19210 (LA326_19210) 4039933..4041843 - 1911 WP_048999489.1 PRD domain-containing protein -
LA326_RS19215 (LA326_19215) 4041863..4042999 - 1137 WP_088204685.1 lactonase family protein -
LA326_RS19220 (LA326_19220) 4043025..4043765 - 741 WP_041911457.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10991.91 Da        Isoelectric Point: 10.0526

>T217017 WP_088204684.1 NZ_CP083643:c4039623-4039339 [Enterobacter bugandensis]
MIYELEFDPRALKEWHKLGDTVKCQFKKKLADVLVNPRIESARLHGLSDCYKIKLRSLGYRLVYQVQDNVVTVFVIAIGK
REKSAVYHEANKRL

Download         Length: 285 bp

>T217017 NZ_CP113540:358942-359217 [Salmonella enterica]
ATGGGGCAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9030.41 Da        Isoelectric Point: 4.7719

>AT217017 WP_023331889.1 NZ_CP083643:c4039855-4039613 [Enterobacter bugandensis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDELIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT217017 NZ_CP113540:358679-358939 [Salmonella enterica]
ATGGCTGCAAATGCGCTTGTTCGTGCCCGTATCGACGAAACGCTGAAGGACCAGGCGGCAGATGTCCTGGCTGAAATGGG
GTTAACCATTTCTGATTTGATACGGATTACACTGACTAAAGTTGCGCGTGAAAAGGCATTGCCTTTTGATTTGCGCATAC
CCAATGAGTTAACGTCACGAACGATAGAAAATAGCGAAGCTGGCGTTGATATTCATAAAGCCAAAGATGCTGATGATTTG
TTTGACCAGTTAGGGATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References