Detailed information of TA system TA217015

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 2941399..2942312
• Replicon: chromosome
• Accession: NZ_CP083643
• Organism: Enterobacter bugandensis strain FDAARGOS_1496

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LA326_RS14050
• Protein ID: WP_088204937.1
• Coordinates: 2941839..2942312 (+)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LA326_RS14045
• Protein ID: WP_045261776.1
• Coordinates: 2941399..2941842 (+)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA326_RS14030 (LA326_14030)	2937807..2939528	+	1722	WP_088204938.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-
LA326_RS14035 (LA326_14035)	2939574..2940278	+	705	WP_041910636.1	leucyl/phenylalanyl-tRNA--protein transferase	-
LA326_RS14040 (LA326_14040)	2940563..2940781	+	219	WP_002211347.1	translation initiation factor IF-1	-
LA326_RS14045 (LA326_14045)	2941399..2941842	+	444	WP_045261776.1	DUF2384 domain-containing protein	Antitoxin
LA326_RS14050 (LA326_14050)	2941839..2942312	+	474	WP_088204937.1	RES domain-containing protein	Toxin
LA326_RS14055 (LA326_14055)	2942335..2942889	-	555	WP_088204936.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
LA326_RS14060 (LA326_14060)	2942899..2943897	-	999	WP_045261779.1	type I-F CRISPR-associated protein Csy3	-
LA326_RS14065 (LA326_14065)	2943911..2944846	-	936	WP_088204935.1	type I-F CRISPR-associated protein Csy2	-
LA326_RS14070 (LA326_14070)	2944843..2946153	-	1311	WP_088204934.1	type I-F CRISPR-associated protein Csy1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (30-90)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17531.88 Da
• Isoelectric Point: 5.0700

>T217015 WP_088204937.1 NZ_CP083643:2941839-2942312 [Enterobacter bugandensis]
MIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHIRKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQASSALALILPSCIIPYENNAILNPLHPAFHTALSSVQQMPFIFDTRLAEKTAP

Nucleotide

• Length: 474 bp

>T217015 NZ_CP113540:200452-200937 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGTGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16365.72 Da
• Isoelectric Point: 8.5886

>AT217015 WP_045261776.1 NZ_CP083643:2941399-2941842 [Enterobacter bugandensis]
MRTWIPAKKPADNALWRYAGLPANRGMRLIEFLNQGLPVSVLDNIHEWTAMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQSPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT217015 NZ_CP113540:200177-200464 [Salmonella enterica]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCAGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA