Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | kacAT/DUF1778(antitoxin) |
| Location | 2808737..2809534 | Replicon | chromosome |
| Accession | NZ_CP083643 | ||
| Organism | Enterobacter bugandensis strain FDAARGOS_1496 | ||
Toxin (Protein)
| Gene name | KacT | Uniprot ID | - |
| Locus tag | LA326_RS13430 | Protein ID | WP_172616463.1 |
| Coordinates | 2808737..2809237 (-) | Length | 167 a.a. |
Antitoxin (Protein)
| Gene name | KacA | Uniprot ID | W7PG43 |
| Locus tag | LA326_RS13435 | Protein ID | WP_008499829.1 |
| Coordinates | 2809265..2809534 (-) | Length | 90 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LA326_RS13400 (LA326_13400) | 2804335..2805024 | + | 690 | WP_028012657.1 | pyrimidine utilization protein B | - |
| LA326_RS13405 (LA326_13405) | 2805036..2805422 | + | 387 | WP_088204983.1 | pyrimidine utilization protein C | - |
| LA326_RS13410 (LA326_13410) | 2805430..2806230 | + | 801 | WP_028012656.1 | pyrimidine utilization protein D | - |
| LA326_RS13415 (LA326_13415) | 2806240..2806830 | + | 591 | WP_041910551.1 | malonic semialdehyde reductase | - |
| LA326_RS13420 (LA326_13420) | 2806840..2807334 | + | 495 | WP_028012654.1 | pyrimidine utilization flavin reductase protein F | - |
| LA326_RS13425 (LA326_13425) | 2807356..2808678 | + | 1323 | WP_048959639.1 | pyrimidine utilization transport protein G | - |
| LA326_RS13430 (LA326_13430) | 2808737..2809237 | - | 501 | WP_172616463.1 | GNAT family N-acetyltransferase | Toxin |
| LA326_RS13435 (LA326_13435) | 2809265..2809534 | - | 270 | WP_008499829.1 | DUF1778 domain-containing protein | Antitoxin |
| LA326_RS13440 (LA326_13440) | 2809596..2810513 | - | 918 | WP_088204981.1 | DMT family transporter | - |
| LA326_RS13445 (LA326_13445) | 2810630..2810800 | - | 171 | WP_001273664.1 | general stress protein | - |
| LA326_RS13450 (LA326_13450) | 2811191..2811787 | + | 597 | WP_041910554.1 | NAD(P)H:quinone oxidoreductase | - |
| LA326_RS13455 (LA326_13455) | 2811806..2812033 | + | 228 | WP_028012649.1 | YccJ family protein | - |
| LA326_RS13460 (LA326_13460) | 2812067..2813308 | - | 1242 | WP_088204980.1 | bifunctional glucose-1-phosphatase/inositol phosphatase | - |
| LA326_RS13465 (LA326_13465) | 2813461..2813904 | + | 444 | WP_028012647.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 167 a.a. Molecular weight: 18873.63 Da Isoelectric Point: 8.4785
>T217014 WP_172616463.1 NZ_CP083643:c2809237-2808737 [Enterobacter bugandensis]
MFSEGTDYDFGDFDCGEPSLNAFLREHLVRQHNGRILRAYLLKERDHPRVLGYYTLSGSCFERAMLPSKTQQRRIPYLNV
PSVTLGRLAIHKELQGNEWGTTLVAHAMRVVYLASQAVGVHGIFVDALSEQAKRFYLKLGFIPLAGENSHSLFFPTKAIE
RLFEQA
MFSEGTDYDFGDFDCGEPSLNAFLREHLVRQHNGRILRAYLLKERDHPRVLGYYTLSGSCFERAMLPSKTQQRRIPYLNV
PSVTLGRLAIHKELQGNEWGTTLVAHAMRVVYLASQAVGVHGIFVDALSEQAKRFYLKLGFIPLAGENSHSLFFPTKAIE
RLFEQA
Download Length: 501 bp
>T217014 NZ_CP113539:4531476-4531787 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTTGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATAAAGAATGA
Antitoxin
Download Length: 90 a.a. Molecular weight: 10262.72 Da Isoelectric Point: 5.8836
>AT217014 WP_008499829.1 NZ_CP083643:c2809534-2809265 [Enterobacter bugandensis]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME
Download Length: 270 bp
>AT217014 NZ_CP113539:4531784-4532230 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|