217005

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 669334..669991 Replicon chromosome
Accession NZ_CP083643
Organism Enterobacter bugandensis strain FDAARGOS_1496

Toxin (Protein)


Gene name cptA Uniprot ID A0A2J7SFN6
Locus tag LA326_RS03270 Protein ID WP_028014322.1
Coordinates 669581..669991 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag LA326_RS03265 Protein ID WP_010435322.1
Coordinates 669334..669600 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA326_RS03245 (LA326_03245) 664765..666198 - 1434 WP_059358111.1 6-phospho-beta-glucosidase BglA -
LA326_RS03250 (LA326_03250) 666315..667046 - 732 WP_028014325.1 MurR/RpiR family transcriptional regulator -
LA326_RS03255 (LA326_03255) 667312..667971 + 660 WP_023331242.1 hemolysin III family protein -
LA326_RS03260 (LA326_03260) 668059..669039 - 981 WP_048960833.1 tRNA-modifying protein YgfZ -
LA326_RS03265 (LA326_03265) 669334..669600 + 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
LA326_RS03270 (LA326_03270) 669581..669991 + 411 WP_028014322.1 protein YgfX Toxin
LA326_RS03275 (LA326_03275) 669998..670519 - 522 WP_041908355.1 flavodoxin FldB -
LA326_RS03280 (LA326_03280) 670621..671517 + 897 WP_028014320.1 site-specific tyrosine recombinase XerD -
LA326_RS03285 (LA326_03285) 671546..672259 + 714 WP_049136419.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LA326_RS03290 (LA326_03290) 672265..673998 + 1734 WP_041908356.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16024.98 Da        Isoelectric Point: 11.2845

>T217005 WP_028014322.1 NZ_CP083643:669581-669991 [Enterobacter bugandensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGVPWMLNAGMMLRLRKVGGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T217005 NZ_CP113539:853055-853453 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTCTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCCGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAGTTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT217005 WP_010435322.1 NZ_CP083643:669334-669600 [Enterobacter bugandensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT217005 NZ_CP113539:852828-853055 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGTAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J7SFN6

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References