Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3678145..3678802 Replicon chromosome
Accession NZ_CP083641
Organism Enterobacter bugandensis strain FDAARGOS_1497

Toxin (Protein)


Gene name cptA Uniprot ID A0A2J7SFN6
Locus tag LA318_RS17420 Protein ID WP_028014322.1
Coordinates 3678145..3678555 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID V3PWU7
Locus tag LA318_RS17425 Protein ID WP_010435322.1
Coordinates 3678536..3678802 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA318_RS17400 (LA318_17400) 3674138..3675871 - 1734 WP_041908356.1 single-stranded-DNA-specific exonuclease RecJ -
LA318_RS17405 (LA318_17405) 3675877..3676590 - 714 WP_049136419.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LA318_RS17410 (LA318_17410) 3676619..3677515 - 897 WP_028014320.1 site-specific tyrosine recombinase XerD -
LA318_RS17415 (LA318_17415) 3677617..3678138 + 522 WP_041908355.1 flavodoxin FldB -
LA318_RS17420 (LA318_17420) 3678145..3678555 - 411 WP_028014322.1 protein YgfX Toxin
LA318_RS17425 (LA318_17425) 3678536..3678802 - 267 WP_010435322.1 FAD assembly factor SdhE Antitoxin
LA318_RS17430 (LA318_17430) 3679097..3680077 + 981 WP_048960833.1 tRNA-modifying protein YgfZ -
LA318_RS17435 (LA318_17435) 3680165..3680824 - 660 WP_023331242.1 hemolysin III family protein -
LA318_RS17440 (LA318_17440) 3681090..3681821 + 732 WP_028014325.1 MurR/RpiR family transcriptional regulator -
LA318_RS17445 (LA318_17445) 3681938..3683371 + 1434 WP_059358111.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16024.98 Da        Isoelectric Point: 11.2845

>T217002 WP_028014322.1 NZ_CP083641:c3678555-3678145 [Enterobacter bugandensis]
VVLWQSDLRVSWRSQWMSLLLHGLVAAIVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGVPWMLNAGMMLRLRKVGGGRCQHLWLAADSMDASEWRDLRRMLLQQPTQE

Download         Length: 411 bp

>T217002 NZ_CP113539:219867-220352 [Salmonella enterica]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTCGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTACAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGAGCTCTCATTCCATGGAAAAGGGCTTGGGGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCAAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1340

>AT217002 WP_010435322.1 NZ_CP083641:c3678802-3678536 [Enterobacter bugandensis]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT217002 NZ_CP113539:219592-219879 [Salmonella enterica]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J7SFN6

Antitoxin

Source ID Structure
AlphaFold DB V3PWU7

References