Detailed information of TA system TA216992

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1405824..1406737
• Replicon: chromosome
• Accession: NZ_CP083641
• Organism: Enterobacter bugandensis strain FDAARGOS_1497

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LA318_RS06645
• Protein ID: WP_088204937.1
• Coordinates: 1405824..1406297 (-)
• Length: 158 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LA318_RS06650
• Protein ID: WP_045261776.1
• Coordinates: 1406294..1406737 (-)
• Length: 148 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA318_RS06625 (LA318_06625)	1401983..1403293	+	1311	WP_088204934.1	type I-F CRISPR-associated protein Csy1	-
LA318_RS06630 (LA318_06630)	1403290..1404225	+	936	WP_088204935.1	type I-F CRISPR-associated protein Csy2	-
LA318_RS06635 (LA318_06635)	1404239..1405237	+	999	WP_045261779.1	type I-F CRISPR-associated protein Csy3	-
LA318_RS06640 (LA318_06640)	1405247..1405801	+	555	WP_088204936.1	type I-F CRISPR-associated endoribonuclease Cas6/Csy4	-
LA318_RS06645 (LA318_06645)	1405824..1406297	-	474	WP_088204937.1	RES domain-containing protein	Toxin
LA318_RS06650 (LA318_06650)	1406294..1406737	-	444	WP_045261776.1	DUF2384 domain-containing protein	Antitoxin
LA318_RS06655 (LA318_06655)	1407355..1407573	-	219	WP_002211347.1	translation initiation factor IF-1	-
LA318_RS06660 (LA318_06660)	1407858..1408562	-	705	WP_041910636.1	leucyl/phenylalanyl-tRNA--protein transferase	-
LA318_RS06665 (LA318_06665)	1408608..1410329	-	1722	WP_088204938.1	cysteine/glutathione ABC transporter ATP-binding protein/permease CydC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre-like, helix-turn-helix domain (30-90)

Sequences

Toxin

Protein

• Length: 158 a.a.
• Molecular weight: 17531.88 Da
• Isoelectric Point: 5.0700

>T216992 WP_088204937.1 NZ_CP083641:c1406297-1405824 [Enterobacter bugandensis]
MIFYRLVTGRYASEAWSGSGANQYGGRWNHKGHPAVYVSTSISLASLEILVHIRKDTVLNQYQLFSIDIPDDQIDYLDKA
WLPEDWQENPAPVSTMDLGTGWLQASSALALILPSCIIPYENNAILNPLHPAFHTALSSVQQMPFIFDTRLAEKTAP

Nucleotide

• Length: 474 bp

>T216992 NZ_CP113538:c1024741-1024214 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin

Protein

• Length: 148 a.a.
• Molecular weight: 16365.72 Da
• Isoelectric Point: 8.5886

>AT216992 WP_045261776.1 NZ_CP083641:c1406737-1406294 [Enterobacter bugandensis]
MRTWIPAKKPADNALWRYAGLPANRGMRLIEFLNQGLPVSVLDNIHEWTAMSKADILRVTGINERNVARRKSAGRTLTPD
ESERVARFVRVLDAAVDYFGSKEEAWNWLQSPVRGLGNVAPVDLIATETGALEVTDLIGRLEHGVFA

Nucleotide

• Length: 444 bp

>AT216992 NZ_CP113538:c1025028-1024738 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA