Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1603825..1604445 Replicon chromosome
Accession NZ_CP083640
Organism Enterobacter ludwigii strain FDAARGOS_1498

Toxin (Protein)


Gene name Hha Uniprot ID G8LPY2
Locus tag LA317_RS07820 Protein ID WP_014168902.1
Coordinates 1603825..1604043 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID W0BRV6
Locus tag LA317_RS07825 Protein ID WP_020885187.1
Coordinates 1604071..1604445 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA317_RS07790 (LA317_07790) 1599836..1600096 + 261 WP_010428154.1 type B 50S ribosomal protein L31 -
LA317_RS07795 (LA317_07795) 1600099..1600239 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
LA317_RS07800 (LA317_07800) 1600236..1600946 - 711 WP_020885191.1 GNAT family protein -
LA317_RS07805 (LA317_07805) 1601047..1602507 + 1461 WP_223398367.1 PLP-dependent aminotransferase family protein -
LA317_RS07810 (LA317_07810) 1602479..1602946 - 468 WP_020885189.1 YlaC family protein -
LA317_RS07815 (LA317_07815) 1603064..1603615 - 552 WP_020885188.1 maltose O-acetyltransferase -
LA317_RS07820 (LA317_07820) 1603825..1604043 - 219 WP_014168902.1 HHA domain-containing protein Toxin
LA317_RS07825 (LA317_07825) 1604071..1604445 - 375 WP_020885187.1 Hha toxicity modulator TomB Antitoxin
LA317_RS07830 (LA317_07830) 1604957..1608103 - 3147 WP_223398366.1 multidrug efflux RND transporter permease subunit AcrB -
LA317_RS07835 (LA317_07835) 1608126..1609319 - 1194 WP_020885186.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8654.04 Da        Isoelectric Point: 8.9107

>T216981 WP_014168902.1 NZ_CP083640:c1604043-1603825 [Enterobacter ludwigii]
MSEKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWRFVR

Download         Length: 219 bp

>T216981 NZ_CP113537:1984704-1984807 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14495.31 Da        Isoelectric Point: 4.8886

>AT216981 WP_020885187.1 NZ_CP083640:c1604445-1604071 [Enterobacter ludwigii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFINVSRANPVSLSC

Download         Length: 375 bp

>AT216981 NZ_CP113537:c1984809-1984666 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BM33

Antitoxin

Source ID Structure
AlphaFold DB A0A5C1BX74

References