Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1047031..1047502 Replicon chromosome
Accession NZ_CP083640
Organism Enterobacter ludwigii strain FDAARGOS_1498

Toxin (Protein)


Gene name relE Uniprot ID A0A839BQT8
Locus tag LA317_RS05185 Protein ID WP_020885403.1
Coordinates 1047263..1047502 (+) Length 80 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A839BTQ9
Locus tag LA317_RS05180 Protein ID WP_020885404.1
Coordinates 1047031..1047273 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA317_RS05165 (LA317_05165) 1043028..1043768 + 741 WP_020882900.1 KDGP aldolase family protein -
LA317_RS05170 (LA317_05170) 1043887..1045023 + 1137 WP_020885406.1 lactonase family protein -
LA317_RS05175 (LA317_05175) 1045043..1046953 + 1911 WP_020885405.1 PRD domain-containing protein -
LA317_RS05180 (LA317_05180) 1047031..1047273 + 243 WP_020885404.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LA317_RS05185 (LA317_05185) 1047263..1047502 + 240 WP_020885403.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LA317_RS05190 (LA317_05190) 1047551..1048015 - 465 WP_020885402.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LA317_RS05195 (LA317_05195) 1048154..1050292 - 2139 WP_020885401.1 anaerobic ribonucleoside-triphosphate reductase -
LA317_RS05200 (LA317_05200) 1050660..1051232 - 573 WP_149376281.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-77)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 80 a.a.        Molecular weight: 9093.63 Da        Isoelectric Point: 9.9348

>T216980 WP_020885403.1 NZ_CP083640:1047263-1047502 [Enterobacter ludwigii]
MTYELVFDPRAFKEWTRLGDTVKNQFKKKLANVLVNPRVESARLHGLPDCDKIKLRSQGYRLVYQVQDNVVTVCVIAIG

Download         Length: 240 bp

>T216980 NZ_CP083640:1047263-1047502 [Enterobacter ludwigii]
ATGACTTATGAACTCGTATTTGATCCGAGGGCGTTCAAGGAGTGGACCAGGCTGGGTGATACCGTAAAAAATCAGTTTAA
GAAGAAGCTTGCGAACGTGTTGGTGAACCCCAGGGTTGAATCGGCTCGCCTGCATGGCCTGCCTGATTGCGACAAGATAA
AACTCAGATCCCAGGGTTATCGTTTGGTCTATCAGGTTCAGGACAACGTTGTGACGGTATGTGTTATTGCTATCGGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9085.49 Da        Isoelectric Point: 5.1088

>AT216980 WP_020885404.1 NZ_CP083640:1047031-1047273 [Enterobacter ludwigii]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTVSDSEDELIQTVRERLANPQKGIKVRLDDL

Download         Length: 243 bp

>AT216980 NZ_CP083640:1047031-1047273 [Enterobacter ludwigii]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTTGAAAAACTCAATATCACGCC
AACGGAAGCCGTTCGGTTACTGTTTCAGTACGTTGCGGAGACGGGGCGTATGCCGGTGAAAACGGTCACTGTTAGCGACA
GTGAAGATGAACTCATACAGACAGTCCGGGAGCGGTTGGCTAATCCGCAAAAAGGAATTAAGGTTAGGCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BQT8

Antitoxin

Source ID Structure
AlphaFold DB A0A839BTQ9

References