Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/VapC-StbC |
| Location | 76413..77089 | Replicon | plasmid pRL12 |
| Accession | NC_008378 | ||
| Organism | Rhizobium leguminosarum bv. viciae 3841 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | Q1M527 |
| Locus tag | RL_RS33320 | Protein ID | WP_011648871.1 |
| Coordinates | 76664..77089 (+) | Length | 142 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | Q1M528 |
| Locus tag | RL_RS33315 | Protein ID | WP_011648870.1 |
| Coordinates | 76413..76667 (+) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RL_RS33285 | 71462..72265 | - | 804 | WP_011648864.1 | crotonase/enoyl-CoA hydratase family protein | - |
| RL_RS33290 | 72303..72944 | + | 642 | WP_049778479.1 | TetR/AcrR family transcriptional regulator | - |
| RL_RS33295 | 73201..74040 | + | 840 | WP_011648866.1 | transporter substrate-binding domain-containing protein | - |
| RL_RS33300 | 74158..74820 | + | 663 | WP_028742556.1 | amino acid ABC transporter permease | - |
| RL_RS33305 | 74826..75485 | + | 660 | WP_011648868.1 | amino acid ABC transporter permease | - |
| RL_RS33310 | 75498..76268 | + | 771 | WP_011648869.1 | amino acid ABC transporter ATP-binding protein | - |
| RL_RS33315 | 76413..76667 | + | 255 | WP_011648870.1 | plasmid stabilization protein | Antitoxin |
| RL_RS33320 | 76664..77089 | + | 426 | WP_011648871.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| RL_RS33325 | 77283..78044 | + | 762 | WP_011648872.1 | GntR family transcriptional regulator | - |
| RL_RS33330 | 78038..78823 | + | 786 | WP_011648873.1 | transporter substrate-binding domain-containing protein | - |
| RL_RS33335 | 78901..79572 | + | 672 | WP_011648874.1 | amino acid ABC transporter permease | - |
| RL_RS33340 | 79569..80228 | + | 660 | WP_011648875.1 | amino acid ABC transporter permease | - |
| RL_RS33345 | 80206..80931 | + | 726 | WP_011648876.1 | amino acid ABC transporter ATP-binding protein | - |
| RL_RS33350 | 80979..81350 | - | 372 | WP_011648877.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| RL_RS33355 | 81350..81607 | - | 258 | WP_011648878.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..870021 | 870021 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 142 a.a. Molecular weight: 14976.18 Da Isoelectric Point: 4.8838
>T21698 WP_011648871.1 NC_008378:76664-77089 [Rhizobium leguminosarum bv. viciae 3841]
MIILDTNVVSEAMKPTPDEAVKFWLDEQAAETLFLSSVTIAELMFGIGALPAGKRRERLSDALDGLMELFESRILAFDIT
AARHYADLAVKARAAGRGFPTPDGYIAAIAASKGFAVATRDTSAFNAAGVKVINPWAASTA
MIILDTNVVSEAMKPTPDEAVKFWLDEQAAETLFLSSVTIAELMFGIGALPAGKRRERLSDALDGLMELFESRILAFDIT
AARHYADLAVKARAAGRGFPTPDGYIAAIAASKGFAVATRDTSAFNAAGVKVINPWAASTA
Download Length: 426 bp
>T21698 NC_008378:76664-77089 [Rhizobium leguminosarum bv. viciae 3841]
ATGATTATCCTCGATACGAACGTTGTTTCCGAGGCGATGAAACCCACGCCCGACGAAGCCGTGAAATTCTGGCTCGATGA
GCAGGCAGCCGAAACCCTGTTCCTTTCTAGCGTCACGATCGCCGAACTGATGTTTGGAATCGGCGCGCTCCCGGCTGGCA
AGCGCAGGGAAAGGCTCTCCGACGCGTTGGACGGTCTGATGGAGCTCTTCGAAAGCCGTATTTTGGCTTTCGACATCACA
GCGGCACGGCACTATGCCGATCTCGCCGTCAAGGCCCGAGCCGCTGGCAGAGGATTCCCCACTCCGGATGGCTATATCGC
CGCCATCGCAGCATCAAAAGGGTTCGCCGTCGCCACGCGCGATACAAGTGCTTTCAACGCTGCGGGCGTTAAAGTGATCA
ATCCCTGGGCGGCTTCGACCGCATAA
ATGATTATCCTCGATACGAACGTTGTTTCCGAGGCGATGAAACCCACGCCCGACGAAGCCGTGAAATTCTGGCTCGATGA
GCAGGCAGCCGAAACCCTGTTCCTTTCTAGCGTCACGATCGCCGAACTGATGTTTGGAATCGGCGCGCTCCCGGCTGGCA
AGCGCAGGGAAAGGCTCTCCGACGCGTTGGACGGTCTGATGGAGCTCTTCGAAAGCCGTATTTTGGCTTTCGACATCACA
GCGGCACGGCACTATGCCGATCTCGCCGTCAAGGCCCGAGCCGCTGGCAGAGGATTCCCCACTCCGGATGGCTATATCGC
CGCCATCGCAGCATCAAAAGGGTTCGCCGTCGCCACGCGCGATACAAGTGCTTTCAACGCTGCGGGCGTTAAAGTGATCA
ATCCCTGGGCGGCTTCGACCGCATAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9361.70 Da Isoelectric Point: 10.6531
>AT21698 WP_011648870.1 NC_008378:76413-76667 [Rhizobium leguminosarum bv. viciae 3841]
MPAVTIRNLSEATHRALKVRAAHHGRSAEAEMREILEAAVRPETRLRLGSALAERSRRLGLTNEDFAVLDQARDTLPAKP
MSFE
MPAVTIRNLSEATHRALKVRAAHHGRSAEAEMREILEAAVRPETRLRLGSALAERSRRLGLTNEDFAVLDQARDTLPAKP
MSFE
Download Length: 255 bp
>AT21698 NC_008378:76413-76667 [Rhizobium leguminosarum bv. viciae 3841]
ATGCCCGCAGTCACAATCAGAAACCTCTCCGAGGCGACGCACCGTGCTCTCAAGGTGCGTGCGGCTCATCACGGGCGCAG
CGCCGAAGCGGAAATGCGGGAAATCCTCGAGGCTGCCGTGCGTCCAGAAACGCGGCTTCGTCTTGGTAGCGCACTCGCCG
AACGGAGCCGCCGCCTCGGACTGACGAATGAGGACTTTGCCGTTCTGGACCAAGCTCGCGACACATTGCCTGCAAAGCCG
ATGAGCTTTGAATGA
ATGCCCGCAGTCACAATCAGAAACCTCTCCGAGGCGACGCACCGTGCTCTCAAGGTGCGTGCGGCTCATCACGGGCGCAG
CGCCGAAGCGGAAATGCGGGAAATCCTCGAGGCTGCCGTGCGTCCAGAAACGCGGCTTCGTCTTGGTAGCGCACTCGCCG
AACGGAGCCGCCGCCTCGGACTGACGAATGAGGACTTTGCCGTTCTGGACCAAGCTCGCGACACATTGCCTGCAAAGCCG
ATGAGCTTTGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q1M527 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A7Y3S1G5 |