Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 636928..637585 Replicon chromosome
Accession NZ_CP083640
Organism Enterobacter ludwigii strain FDAARGOS_1498

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag LA317_RS03175 Protein ID WP_014171514.1
Coordinates 637175..637585 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag LA317_RS03170 Protein ID WP_003863437.1
Coordinates 636928..637194 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA317_RS03150 (LA317_03150) 632335..633768 - 1434 WP_020883728.1 6-phospho-beta-glucosidase BglA -
LA317_RS03155 (LA317_03155) 633885..634616 - 732 WP_020883729.1 MurR/RpiR family transcriptional regulator -
LA317_RS03160 (LA317_03160) 634883..635542 + 660 WP_014171517.1 hemolysin III family protein -
LA317_RS03165 (LA317_03165) 635653..636633 - 981 WP_047356717.1 tRNA-modifying protein YgfZ -
LA317_RS03170 (LA317_03170) 636928..637194 + 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
LA317_RS03175 (LA317_03175) 637175..637585 + 411 WP_014171514.1 protein YgfX Toxin
LA317_RS03180 (LA317_03180) 637592..638113 - 522 WP_014171513.1 flavodoxin FldB -
LA317_RS03185 (LA317_03185) 638215..639111 + 897 WP_223398772.1 site-specific tyrosine recombinase XerD -
LA317_RS03190 (LA317_03190) 639135..639848 + 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LA317_RS03195 (LA317_03195) 639854..641587 + 1734 WP_223398773.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T216979 WP_014171514.1 NZ_CP083640:637175-637585 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

>T216979 NZ_CP113537:c1008747-1008220 [Salmonella enterica]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGTACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCTCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT216979 WP_003863437.1 NZ_CP083640:636928-637194 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp

>AT216979 NZ_CP113537:c1009034-1008744 [Salmonella enterica]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTGCGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCTGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References