Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 53240..53883 Replicon plasmid unnamed
Accession NZ_CP083639
Organism Escherichia fergusonii strain FDAARGOS_1499

Toxin (Protein)


Gene name vagD Uniprot ID Q84A06
Locus tag LA347_RS22295 Protein ID WP_000754566.1
Coordinates 53240..53656 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID Q84A07
Locus tag LA347_RS22300 Protein ID WP_001261276.1
Coordinates 53653..53883 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA347_RS22275 (LA347_22275) 49721..50524 + 804 WP_001082319.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -
LA347_RS22280 (LA347_22280) 50524..51360 + 837 WP_000480968.1 aminoglycoside O-phosphotransferase APH(6)-Id -
LA347_RS22285 (LA347_22285) 51467..51898 - 432 Protein_45 IS110 family transposase -
LA347_RS22290 (LA347_22290) 52180..53036 - 857 Protein_46 IS3 family transposase -
LA347_RS22295 (LA347_22295) 53240..53656 - 417 WP_000754566.1 type II toxin-antitoxin system VapC family toxin Toxin
LA347_RS22300 (LA347_22300) 53653..53883 - 231 WP_001261276.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LA347_RS22305 (LA347_22305) 54457..54807 + 351 WP_000493378.1 hypothetical protein -
LA347_RS22310 (LA347_22310) 54858..55601 + 744 WP_000129823.1 hypothetical protein -
LA347_RS22315 (LA347_22315) 55598..56374 + 777 WP_000015958.1 site-specific integrase -
LA347_RS22320 (LA347_22320) 56432..56689 - 258 WP_000764641.1 hypothetical protein -
LA347_RS22325 (LA347_22325) 56818..56922 - 105 WP_032409716.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaTEM-1B / tet(B) / aph(3'')-Ib / aph(6)-Id - 1..57214 57214


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(6-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15006.52 Da        Isoelectric Point: 9.2957

>T216978 WP_000754566.1 NZ_CP083639:c53656-53240 [Escherichia fergusonii]
MKKTWMLDTNICSFIMREQPAAVLKRLEQAVLRGDRIVVSAVTYAEMRFGATGPKASPRHIQLVDAFCARLDAVLPWDRA
AVDATTDIRVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNVREFARVPGLVLEDWVK

Download         Length: 417 bp

>T216978 NZ_CP113537:843768-844181 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGAGAGATCAAGCTACTCATGGACGGCCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAAAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8721.74 Da        Isoelectric Point: 4.3533

>AT216978 WP_001261276.1 NZ_CP083639:c53883-53653 [Escherichia fergusonii]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLDRADPDFMAEREDVVSDEGRFEP

Download         Length: 231 bp

>AT216978 NZ_CP113537:843521-843787 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A387K1G3

Antitoxin

Source ID Structure
AlphaFold DB A0A387K023

References