Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4577373..4578027 Replicon chromosome
Accession NZ_CP083638
Organism Escherichia fergusonii strain FDAARGOS_1499

Toxin (Protein)


Gene name cptA Uniprot ID B7LPA9
Locus tag LA347_RS22010 Protein ID WP_000244784.1
Coordinates 4577620..4578027 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag LA347_RS22005 Protein ID WP_000354046.1
Coordinates 4577373..4577639 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA347_RS21980 (4572511) 4572511..4573404 + 894 WP_000819362.1 transporter -
LA347_RS21985 (4573452) 4573452..4574885 - 1434 WP_024256520.1 6-phospho-beta-glucosidase BglA -
LA347_RS21990 (4574930) 4574930..4575241 + 312 WP_001182961.1 N(4)-acetylcytidine aminohydrolase -
LA347_RS21995 (4575405) 4575405..4576064 + 660 WP_000250283.1 hemolysin III family protein -
LA347_RS22000 (4576141) 4576141..4577121 - 981 WP_000886105.1 tRNA-modifying protein YgfZ -
LA347_RS22005 (4577373) 4577373..4577639 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
LA347_RS22010 (4577620) 4577620..4578027 + 408 WP_000244784.1 protein YgfX Toxin
LA347_RS22015 (4578067) 4578067..4578588 - 522 WP_001055871.1 flavodoxin FldB -
LA347_RS22020 (4578700) 4578700..4579596 + 897 WP_000806646.1 site-specific tyrosine recombinase XerD -
LA347_RS22025 (4579621) 4579621..4580331 + 711 WP_000715223.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
LA347_RS22030 (4580337) 4580337..4582070 + 1734 WP_000813234.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16094.05 Da        Isoelectric Point: 11.2511

>T216977 WP_000244784.1 NZ_CP083638:4577620-4578027 [Escherichia fergusonii]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINSRQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T216977 NZ_CP113537:324065-324433 [Salmonella enterica]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTATCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCACTATATCCCGTGGGTATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAACAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT216977 WP_000354046.1 NZ_CP083638:4577373-4577639 [Escherichia fergusonii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT216977 NZ_CP113537:323847-324068 [Salmonella enterica]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTAACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGAAGCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B7LPA9

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References