Detailed information of TA system TA021696

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RHH(antitoxin)
• Location: 802079..802648
• Replicon: chromosome
• Accession: NC_008347
• Organism: Maricaulis maris MCS10

Toxin (Protein)

• Gene name: relE
• Uniprot ID: Q0ARU5
• Locus tag: MMAR10_RS03630
• Protein ID: WP_011642639.1
• Coordinates: 802355..802648 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q0ARU6
• Locus tag: MMAR10_RS03625
• Protein ID: WP_011642638.1
• Coordinates: 802079..802348 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMAR10_RS03605	798546..799265	+	720	WP_011642634.1	sel1 repeat family protein	-
MMAR10_RS03610	799305..800198	+	894	WP_011642635.1	sel1 repeat family protein	-
MMAR10_RS15990	800214..800555	-	342	WP_190273955.1	CPBP family intramembrane metalloprotease	-
MMAR10_RS03620	800763..801950	+	1188	WP_011642637.1	thiolase family protein	-
MMAR10_RS03625	802079..802348	+	270	WP_011642638.1	ribbon-helix-helix domain-containing protein	Antitoxin
MMAR10_RS03630	802355..802648	+	294	WP_011642639.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MMAR10_RS03635	802694..803071	-	378	WP_011642640.1	hypothetical protein	-
MMAR10_RS15995	803085..803465	-	381	WP_011642641.1	hypothetical protein	-
MMAR10_RS03645	803511..804074	+	564	WP_011642642.1	TetR/AcrR family transcriptional regulator	-
MMAR10_RS03650	804117..804596	-	480	WP_011642643.1	Lrp/AsnC family transcriptional regulator	-
MMAR10_RS03655	804781..806010	+	1230	WP_011642644.1	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) subunit alpha	-
MMAR10_RS03660	806014..807027	+	1014	WP_011642645.1	alpha-ketoacid dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Ribbon-helix-helix protein, CopG (8-45)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11347.04 Da
• Isoelectric Point: 6.7289

>T21696 WP_011642639.1 NC_008347:802355-802648 [Maricaulis maris MCS10]
MKIEWTARASGDLARLFDFLEPVAPDAAVRVVQEIARAPNRLLYHPRIGEKLDVYEPREVRRIIIGHYEMRYEIAAGTLF
ILRVWHSREDRDFGPEA

Nucleotide

• Length: 294 bp

>T21696 NC_008347:802355-802648 [Maricaulis maris MCS10]
ATGAAGATTGAATGGACCGCCAGGGCCAGCGGTGACCTCGCGAGGCTCTTCGATTTTCTGGAACCTGTGGCTCCGGATGC
GGCGGTCCGGGTAGTCCAGGAAATCGCGCGAGCCCCGAACCGCCTGCTCTATCATCCTCGTATTGGCGAGAAACTGGACG
TTTATGAGCCGCGCGAAGTTCGCCGTATCATCATCGGTCACTACGAGATGCGGTATGAGATTGCCGCCGGCACCCTTTTC
ATCCTGCGGGTCTGGCATAGCCGCGAGGATCGCGATTTTGGTCCGGAGGCCTGA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9611.96 Da
• Isoelectric Point: 4.7734

>AT21696 WP_011642638.1 NC_008347:802079-802348 [Maricaulis maris MCS10]
MSAATRVITAHVPTGLAEKVDAMAARLDRSRGWVMKQALAAWVDQEEERHRLTLEALADVDAGRVVDHGAMLAWVDSLGT
DAPLPPPVE

Nucleotide

• Length: 270 bp

>AT21696 NC_008347:802079-802348 [Maricaulis maris MCS10]
ATGAGCGCTGCAACGCGAGTCATCACGGCGCATGTGCCGACCGGTCTGGCCGAAAAGGTGGATGCCATGGCGGCGCGGCT
TGATCGCTCGCGCGGATGGGTGATGAAGCAGGCGCTAGCCGCCTGGGTCGACCAAGAAGAGGAGCGTCATAGGCTGACGC
TTGAAGCGCTCGCGGACGTCGATGCCGGCCGTGTGGTCGATCACGGGGCCATGCTGGCCTGGGTCGACAGTCTGGGAACC
GACGCGCCCTTGCCGCCGCCTGTCGAATAA

Structures

Toxin

• AlphaFold DB: Q0ARU5

Antitoxin

• AlphaFold DB: Q0ARU6