Detailed information of TA system TA216950

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 5320730..5322318
• Replicon: chromosome
• Accession: NZ_CP083633
• Organism: Klebsiella quasipneumoniae strain FDAARGOS_1503

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LA349_RS25450
• Protein ID: WP_044523012.1
• Coordinates: 5320996..5322318 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LA349_RS25445
• Protein ID: WP_044523009.1
• Coordinates: 5320730..5320996 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA349_RS25420 (5315881)	5315881..5316804	+	924	WP_044522995.1	LysR family hpxDE operon transcriptional regulator HpxR	-
LA349_RS25425 (5316785)	5316785..5317939	-	1155	WP_023289663.1	FAD-dependent urate hydroxylase HpxO	-
LA349_RS25430 (5318285)	5318285..5319664	+	1380	WP_044523001.1	nucleobase:cation symporter-2 family protein	-
LA349_RS25435 (5319642)	5319642..5320142	+	501	WP_044523003.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
LA349_RS25440 (5320139)	5320139..5320465	+	327	WP_044523006.1	hydroxyisourate hydrolase	-
LA349_RS25445 (5320730)	5320730..5320996	+	267	WP_044523009.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LA349_RS25450 (5320996)	5320996..5322318	+	1323	WP_044523012.1	type II toxin-antitoxin system HipA family toxin	Toxin
LA349_RS25455 (5322335)	5322335..5323627	-	1293	WP_044523014.1	glycoside hydrolase family 10 protein	-
LA349_RS25460 (5323769)	5323769..5324773	-	1005	WP_044523017.1	fimbrial protein	-
LA349_RS25465 (5324761)	5324761..5327286	-	2526	WP_044523020.1	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49183.49 Da
• Isoelectric Point: 8.6110

>T216950 WP_044523012.1 NZ_CP083633:5320996-5322318 [Klebsiella quasipneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDDEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATRGRKTEINAIYPRHFLATAKAVNFPRDQMLAILDEFADRVP
QAIESARRTLPADFSAHVWRAITENMLKLHARLQQGLQAR

Nucleotide

• Length: 1323 bp

>T216950 NZ_CP113535:962161-962559 [Salmonella enterica]
ATGCTGAAATTCATGCTTGATACCAATACCTGTATTTTCACCATCAAAAATAAGCCCGAACACATCAGAGAACGCTTCAA
CCTCAATACATCCCGAATGTGTATCAGCTCCATCACCTTAATGGAGCTGATTTACGGTGCTGAAAAAAGCCTGGCGCCGG
AGCGTAATCTTGCCGTCGTGGAGGGATTTATCTCCCGCCTTGAGGTTTTGGATTACGATACACAGGCAGCGATACATACC
GGTCAAATCCGTGCCGAACTGGCCCGCAAGGGAACACCTGTCGGGCCTTATGACCAGATGATTGCTGGCCATGCCGGTAG
CCGCGGACTGGTCGTCGTCACAAACAATCTCCGCGAATTTGAACGCATTCCGGGTATCCGAATCGAAGACTGGTGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9901.29 Da
• Isoelectric Point: 7.3163

>AT216950 WP_044523009.1 NZ_CP083633:5320730-5320996 [Klebsiella quasipneumoniae]
MHPPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETATAP
DNTTDLDW

Nucleotide

• Length: 267 bp

>AT216950 NZ_CP113535:961934-962161 [Salmonella enterica]
ATGCACACAACACTTTTTTTTAGTAACCGGACCCAGGCAGTCAGATTGCCTAAATCGATATCCTTTCCGGAGGATGTGAA
ACATGTCGAAATCATTGCGGTTGGCAGAAGCAGAATCATTACTCCAGTCGGAGAATCCTGGGACAGCTGGTTCGATGGCG
AAGGCGCCAGTACTGATTTTATGAGTACCAGAGAACAACCCGCAGTACAGGAACGGGAAGGATTTTGA