Detailed information of TA system TA021695

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-DinJ
• Location: 1222932..1223466
• Replicon: chromosome
• Accession: NC_008346
• Organism: Syntrophomonas wolfei subsp. wolfei str. Goettingen G311

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: SWOL_RS05465
• Protein ID: WP_011640489.1
• Coordinates: 1223194..1223466 (+)
• Length: 91 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q0AY20
• Locus tag: SWOL_RS05460
• Protein ID: WP_011640488.1
• Coordinates: 1222932..1223201 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SWOL_RS05430	1218136..1218822	-	687	WP_162010599.1	polysaccharide deacetylase family protein	-
SWOL_RS05435	1219106..1219873	+	768	WP_041427826.1	basic amino acid ABC transporter substrate-binding protein	-
SWOL_RS05440	1219955..1220662	+	708	WP_011640485.1	amino acid ABC transporter permease	-
SWOL_RS05445	1220659..1221381	+	723	WP_011640486.1	amino acid ABC transporter ATP-binding protein	-
SWOL_RS14270	1221318..1221653	-	336	WP_155814142.1	S-layer homology domain-containing protein	-
SWOL_RS05455	1221759..1222013	-	255	WP_011640487.1	hypothetical protein	-
SWOL_RS05460	1222932..1223201	+	270	WP_011640488.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SWOL_RS05465	1223194..1223466	+	273	WP_011640489.1	type II toxin-antitoxin system YafQ family toxin	Toxin
SWOL_RS14275	1223823..1225700	-	1878	Protein_1076	Ig domain-containing protein	-
SWOL_RS14280	1225989..1227404	-	1416	Protein_1077	chitobiase/beta-hexosaminidase C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-88)

Sequences

Toxin

Protein

• Length: 91 a.a.
• Molecular weight: 10573.39 Da
• Isoelectric Point: 9.3225

>T21695 WP_011640489.1 NC_008346:1223194-1223466 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
MLKIRYSSRFKKDFKAIVKRGYDVKLLEEVLNLLVQEKVLPQKYLDHPLTGNYAGHRECHITPDWLLIYKIEGDILILSL
TRTGTHSDLY

Nucleotide

• Length: 273 bp

>T21695 NC_008346:1223194-1223466 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
ATGCTTAAAATCAGGTACTCCAGCCGATTTAAAAAAGACTTTAAAGCTATTGTCAAGCGAGGTTATGATGTTAAGCTTCT
CGAAGAAGTTCTTAATCTTCTGGTTCAAGAGAAGGTCCTTCCCCAGAAGTATCTTGATCATCCACTTACCGGTAACTATG
CCGGGCATAGGGAATGCCACATCACACCTGACTGGTTACTAATTTATAAAATTGAAGGGGATATCTTGATATTGTCTTTG
ACACGCACCGGAACCCACAGCGACCTGTATTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10105.41 Da
• Isoelectric Point: 4.3449

>AT21695 WP_011640488.1 NC_008346:1222932-1223201 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
MAKTTNLNIRVDEELKREAEAVFNELGLNMSTAMNIFLRYSVRYGGIPFDLRIEKPNEESMAAIDDVNNNRNMSKTFDSV
SALMEDLNA

Nucleotide

• Length: 270 bp

>AT21695 NC_008346:1222932-1223201 [Syntrophomonas wolfei subsp. wolfei str. Goettingen G311]
ATGGCCAAAACAACCAATTTAAATATTCGTGTCGATGAGGAATTAAAGCGGGAAGCTGAAGCCGTATTTAACGAACTGGG
GCTTAATATGTCCACAGCCATGAATATATTCCTGCGTTACTCCGTTCGCTACGGTGGCATCCCTTTTGATCTCCGCATCG
AAAAGCCCAACGAAGAAAGCATGGCTGCCATTGATGATGTTAATAATAACCGCAATATGAGCAAAACTTTTGATAGTGTA
AGTGCATTAATGGAGGATCTGAATGCTTAA

Structures

Antitoxin

• AlphaFold DB: Q0AY20