Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3921490..3922109 Replicon chromosome
Accession NZ_CP083633
Organism Klebsiella quasipneumoniae strain FDAARGOS_1503

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LA349_RS18820 Protein ID WP_002892050.1
Coordinates 3921490..3921708 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LA349_RS18825 Protein ID WP_002892066.1
Coordinates 3921735..3922109 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA349_RS18785 (3917533) 3917533..3917796 + 264 WP_004204754.1 type B 50S ribosomal protein L31 -
LA349_RS18790 (3917796) 3917796..3917936 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LA349_RS18795 (3917933) 3917933..3918631 - 699 WP_044521289.1 GNAT family protein -
LA349_RS18800 (3918732) 3918732..3920189 + 1458 WP_044521291.1 PLP-dependent aminotransferase family protein -
LA349_RS18805 (3920158) 3920158..3920628 - 471 WP_023288642.1 YlaC family protein -
LA349_RS18810 (3920671) 3920671..3920793 + 123 WP_044521294.1 hypothetical protein -
LA349_RS18815 (3920765) 3920765..3921331 - 567 WP_023288643.1 maltose O-acetyltransferase -
LA349_RS18820 (3921490) 3921490..3921708 - 219 WP_002892050.1 HHA domain-containing protein Toxin
LA349_RS18825 (3921735) 3921735..3922109 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LA349_RS18830 (3922593) 3922593..3925739 - 3147 WP_044521296.1 multidrug efflux RND transporter permease subunit AcrB -
LA349_RS18835 (3925762) 3925762..3926955 - 1194 WP_023288645.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T216949 WP_002892050.1 NZ_CP083633:c3921708-3921490 [Klebsiella quasipneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T216949 NZ_CP113535:951294-951707 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT216949 WP_002892066.1 NZ_CP083633:c3922109-3921735 [Klebsiella quasipneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT216949 NZ_CP113535:951047-951313 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References